Ursane and 24‐Noroleanane‐Type Triterpenoids with Anti‐HIV Activity from the Twigs and Leaves of Antirhea chinensis

Investigations on the twigs and leaves of Antirhea chinensis have led to the discovery of two undescribed pentacyclic triterpenoids (1 and 2) and nine known analogs. Compounds 1 and 2, each assigned as the ursane and 24‐noroleanane‐type triterpenoids, featuring similar oxidation pattern of 3β,6β,19α...

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Bibliographic Details
Published in:Chemistry & biodiversity 2022-10, Vol.19 (10), p.e202200716-n/a
Main Authors: Cui, Jiao‐Jiao, Han, Ying‐Shan, Zhou, Bin, Yue, Jian‐Min
Format: Article
Language:English
Subjects:
24-noroleanane triterpenoid
anti-HIV activity
Antifungal agents
Antirhea
Antirhea chinensis
HIV
Human immunodeficiency virus
Oxidation
Pentacyclic triterpenoids
Selectivity
Triterpenoids
ursane triterpenoid
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Summary:Investigations on the twigs and leaves of Antirhea chinensis have led to the discovery of two undescribed pentacyclic triterpenoids (1 and 2) and nine known analogs. Compounds 1 and 2, each assigned as the ursane and 24‐noroleanane‐type triterpenoids, featuring similar oxidation pattern of 3β,6β,19α‐trihydroxy‐28‐carboxyl. Their structures were elucidated via comprehensive analyses of spectroscopic data. Compound 1 displayed potent anti‐HIV activity (EC50=1.24 μM) and high selectivity index (SI >32.3).
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202200716