Ultrathin trimetallic metal–organic framework nanosheets for accelerating bacteria-infected wound healing

• Published in: Journal of colloid and interface science 2022-12, Vol.628, p.731-744
• Main Authors: Lin, Chuyan, Guo, Xiangjian, Chen, Linxi, You, Tianhui, Lu, Jing, Sun, Duanping
• Format: Article
• Language: English
• Subjects: Antibacterial activity; Metal–organic framework; Nanozyme; Wound healing
• ISSN: 0021-9797; 1095-7103
• DOI: 10.1016/j.jcis.2022.08.073

[Display omitted] •A mild one-pot room temperature solution phase method was developed for the large-scale synthesis of trimetallic NiCoCu-based MOF nanosheets.•The NiCoCu nanosheets with controlled molar ratios have different morphologies, sizes and peroxidase-like catalytic activity.•The (Ni2Co1)0.5Cu0.5 nanosheets showed the best POD-like catalytic performance toward the reduction of H2O2.•The (Ni2Co1)0.5Cu0.5 nanosheets showed the best antibacterial activity against both E Coli. and MRSA bacteria.•The ultrathin trimetallic MOF nanosheets can effectually accelerate bacteria-infected wound healing with excellent biocompatibility. Bacteria-infected wounds are commonly regarded as a hidden threat to human health that can create persistent infection and even bring about amputation or death. Two-dimensional metal–organic frameworks (2D MOFs) with biomimetic enzyme activity have been used to reduce the huge harm caused by antibiotic resistance due to their massive active sites and ultralarge specific surface area. However, their therapeutic efficiency is unsatisfactory because of their relatively low catalytic activity and poor productivity. In this paper, we presented a simple and mild one-pot solution phase method for the large-scale synthesis of NiCoCu-based MOF nanosheets. The NiCoCu nanosheets (denoted as (Ni2Co1)1-xCux) with controlled molar ratios have different morphologies and sizes. Specifically, the (Ni2Co1)0.5Cu0.5 nanosheets showed the best catalytic performance toward the reduction of H2O2 and H2O2 was efficiently catalyzed to generate toxic •OH in the presence of MOF nanosheets with peroxidase-like activity. (Ni2Co1)0.5Cu0.5 exhibited the best antibacterial activity against gram-positive Escherichia coli and methicillin-resistant Staphylococcus aureus bacteria. Animal wound healing experiments demonstrate that ultrathin trimetallic nanosheets can effectively contribute to wound healing with excellent biocompatibility. This study reveals the immense potential of ultrathin trimetallic MOF nanosheets for clinical antibacterial therapy for future pragmatic clinical applications.