Optical coherence tomography angiography characteristics of the retinal and optic disc morphology in prolactinoma

• Published in: Microvascular research 2022-11, Vol.144, p.104424-104424, Article 104424
• Main Authors: Akdogan, Muberra, Dogan, Mustafa, Beysel, Selvihan, Gobeka, Hamidu Hamisi, Sabaner, Mehmet Cem, Oran, Merve
• Format: Article
• Language: English
• Subjects: Morphology; Optic disc; Optical coherence tomography angiography; Prolactinoma; Retinal microvasculature; Retinal nerve fiber layer
• ISSN: 0026-2862; 1095-9319
• DOI: 10.1016/j.mvr.2022.104424

To investigate changes in the retinal and optic disc (OD) morphology in prolactinoma patients without optical chiasmal compression and/or visual field defects using optical coherence tomography angiography (OCTA). In this cross-sectional imaging study, 16 consecutive prolactinoma patients (group 1, 32 eyes) and 15 age- and gender-matched healthy subjects (group 2, 30 eyes) underwent a thorough neuro-ophthalmological examination, which included testing for the presence of any intracranial compressive lesion that could cause optic neuropathy. Retinal morphological parameters, outer retinal and choriocapillaris flow areas, as well as OD vessel density (VD) and retinal nerve fiber layer (RNFL) thickness in for quadrants were then measured using OCTA. Mean age (p = 0.537) and gender (p = 0.385) of participants in groups 1 and 2 did not differ significantly. The mean BCVA for both groups was 0.00 ± 0.00 logMAR. Microadenomas made up the majority of prolactinomas (87.1 %). All retinal morphological parameters in deep capillary plexus (excluding foveal VD) differed significantly between groups 1 and 2 (whole: p