Creatine Monohydrate Supplementation, but not Creatyl-L-Leucine, Increased Muscle Creatine Content in Healthy Young Adults: A Double-Blind Randomized Controlled Trial

Creatine (Cr) supplementation is a well-established strategy to enhance gains in strength, lean body mass, and power from a period of resistance training. However, the effectiveness of creatyl-L-leucine (CLL), a purported Cr amide, is unknown. Therefore, the purpose of this study was to assess the e...

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Published in:International journal of sport nutrition and exercise metabolism 2022-11, Vol.32 (6), p.446-452
Main Authors: Askow, Andrew T, Paulussen, Kevin J M, McKenna, Colleen F, Salvador, Amadeo F, Scaroni, Susannah E, Hamann, Jade S, Ulanov, Alexander V, Li, Zhong, Paluska, Scott A, Beaudry, Kayleigh M, De Lisio, Michael, Burd, Nicholas A
Format: Article
Language:English
Subjects:
Amides - metabolism
Amides - pharmacology
Body Composition - physiology
Creatine
Dietary Supplements
Double-Blind Method
Double-blind studies
Female
Humans
Leucine - metabolism
Leukemia, Lymphocytic, Chronic, B-Cell - metabolism
Male
Muscle Strength
Muscle, Skeletal - physiology
Young Adult
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Summary:Creatine (Cr) supplementation is a well-established strategy to enhance gains in strength, lean body mass, and power from a period of resistance training. However, the effectiveness of creatyl-L-leucine (CLL), a purported Cr amide, is unknown. Therefore, the purpose of this study was to assess the effects of CLL on muscle Cr content. Twenty-nine healthy men (n = 17) and women (n = 12) consumed 5 g/day of either Cr monohydrate (n = 8; 28.5 ± 7.3 years, 172.1 ± 11.0 cm, 76.6 ± 10.7 kg), CLL (n = 11; 29.2 ± 9.3 years, 170.3 ± 10.5 cm, 71.9 ± 14.5 kg), or placebo (n = 10; 30.3 ± 6.9 years, 167.8 ± 9.9 cm, 69.9 ± 11.1 kg) for 14 days in a randomized, double-blind design. Participants completed three bouts of supervised resistance exercise per week. Muscle biopsies were collected before and after the intervention for quantification of muscle Cr. Cr monohydrate supplementation which significantly increased muscle Cr content with 14 days of supplementation. No changes in muscle Cr were observed for the placebo or CLL groups. Cr monohydrate supplementation is an effective strategy to augment muscle Cr content while CLL is not.
ISSN:1526-484X
1543-2742
DOI:10.1123/ijsnem.2022-0074