Anti-Alzheimer's disease potential of traditional chinese medicinal herbs as inhibitors of BACE1 and AChE enzymes

• Published in: Biomedicine & pharmacotherapy 2022-10, Vol.154, p.113576-113576, Article 113576
• Main Authors: Dai, Renhui, Sun, Yingni, Su, Ruiling, Gao, Hongwei
• Format: Article
• Language: English
• Subjects: AChE; BACE1; Chinese medicinal herbs; Inhibitors
• ISSN: 0753-3322; 1950-6007
• DOI: 10.1016/j.biopha.2022.113576

Alzheimer’s disease (AD) is a common neurodegenerative disease that often occurs in the elderly population. At present, most drugs for AD on the market are single-target drugs, which have achieved certain success in the treatment of AD. However, the efficacy and safety of single-target drugs have not achieved the expected results because AD is a multifactorial disease. Multi-targeted drugs act on multiple factors of the disease network to improve efficacy and reduce adverse reactions. Therefore, the search for effective dual-target or even multi-target drugs has become a new research trend. Many of results found that the dual-target inhibitors of the beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) and acetylcholinesterase (AChE) found from traditional Chinese medicine have a good inhibitory effect on AD with fewer side effects. This article reviews sixty-six compounds extracted from Chinese medicinal herbs, which have inhibitory activity on BACE1 and AChE. This provides a theoretical basis for the further development of these compounds as dual-target inhibitors for the treatment of AD. [Display omitted] •ADrequires the development of new molecules with multi-target drug potential.•AChE and BACE1 promotes neuron injury and inflammation in AD.•Summarize the sources, characteristics and anti-AD activities of natural products.•The data should be of great help to design and synthesize new anti-AD agents.