Changes in Cisplatin Delivery Due to Surface-Coated Poly (Lactic Acid)aPoly(Im-Caprolactone) Microspheres

Smooth muscle cell proliferation plays a major role in the genesis of restenosis after angioplasty or vascular injury. Local delivery of agents capable of modulating vascular responses, have the potential to prevent restenosis. However, the development of injectable microspheres for sustained drug d...

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Bibliographic Details
Published in:Journal of biomaterials applications 2002-10, Vol.16 (4), p.275-291
Main Authors: Chandy, Thomas, Wilson, Robert F, Rao, Gundu H R, Das, Gladwin S
Format: Article
Language:English
Online Access:Get full text
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Summary:Smooth muscle cell proliferation plays a major role in the genesis of restenosis after angioplasty or vascular injury. Local delivery of agents capable of modulating vascular responses, have the potential to prevent restenosis. However, the development of injectable microspheres for sustained drug delivery to the arterial wall is a major challenge. We demonstrated the possibility of entrapping an antiproliferative agent, cisplatin, in a series of surface coated biodegradable microspheres composed of poly(lactic acid)a poly(caprolactone) blends, with a mean diameter of 2a10 mm. The microspheres were surface coated with poly ethylene glycol (PEG), chitosan (Chit), or alginate (Alg). A solution of cisplatin and a 50: 50 blend of polylactic acid (PLA)a polycaprolactone (PCL) dissolved in acetoneadichloromethane mixture was poured into an aqueous solution of PEG (or polyvinyl alcohol or Chit or Alg) with stirring using a high speed homogenizer, for the formation of microspheres.
ISSN:0885-3282
DOI:10.1106/088532802024246