Cannabidiol ameliorates the anxiogenic and compulsive-like behaviors induced by chronic consumption of a high-carbohydrate diet in male mice

The excessive consumption of ultra-processed foods and the development of obesity has been associated with several comorbidities, including psychiatric disorders. Excess fat tissue promotes a low-intensity inflammatory state, mainly in the white tissue, which is essential in developing metabolic alt...

Full description

Saved in:
Bibliographic Details
Published in:Metabolic brain disease 2022-12, Vol.37 (8), p.2711-2718
Main Authors: Marçal, Anna Paula, Soares, Nícia, Asth, Laila, Moreira, Fabricio A., Ferreira, Adaliene V. M., Aguiar, Daniele C.
Format: Article
Language:English
Subjects:
Animal models
Anxiety
Behavior
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cannabidiol
Cannabinoids
Cannabis
Carbohydrates
Comorbidity
Diet
Disorders
Food consumption
Food processing
High carbohydrate diet
Homeostasis
Inflammation
Males
Mental disorders
Metabolic Diseases
Neurology
Neurosciences
Obesity
Oncology
Original Article
Processed foods
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The excessive consumption of ultra-processed foods and the development of obesity has been associated with several comorbidities, including psychiatric disorders. Excess fat tissue promotes a low-intensity inflammatory state, mainly in the white tissue, which is essential in developing metabolic alterations and influences brain homeostasis. In this scenario, Cannabidiol (CBD), a compound from C annabis sativa , has presented anxiolytic and anti-inflammatory effects in murine models. This study verified whether CBD treatment would ameliorate the compulsive-like and anxiety-like behaviors observed after mice’s chronic consumption of a high-refined carbohydrate (HC) diet. BALB/c male mice received a control or HC diet for 12 weeks followed by vehicle and CBD (30 mg/Kg, i.p.) administration, and their behavior was evaluated in the Marble Burying test (MB) and Novel Suppressing Feeding test (NSF). The sub-chronic, but not acute, treatment with CBD attenuated the compulsive-like and anxiogenic-like behavior induced by the HC diet. Our data reinforced the harmful effects of the HC diet’s chronic consumption on compulsive and anxious behaviors and the potential of CBD as a drug treatment for psychiatric disorders associated with obesity.
ISSN:0885-7490
1573-7365
DOI:10.1007/s11011-022-01071-9