Facts and Hopes in Cancer Antigens Recognized by T Cells

T cells are key effectors of our immune response against tumors and exert their antitumor effects upon recognizing a variety of tumor-specific peptides presented by HLA molecules on the surface of tumor cells. The identification of the tumor-specific antigens of a given tumor is not required for imm...

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Bibliographic Details
Published in:Clinical cancer research 2023-01, Vol.29 (2), p.309-315
Main Authors: Brochier, Walther, Bricard, Orian, Coulie, Pierre G
Format: Article
Language:English
Subjects:
Antigens, Neoplasm
Humans
Immunotherapy
Neoplasms - genetics
T-Lymphocytes
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Summary:T cells are key effectors of our immune response against tumors and exert their antitumor effects upon recognizing a variety of tumor-specific peptides presented by HLA molecules on the surface of tumor cells. The identification of the tumor-specific antigens of a given tumor is not required for immune checkpoint therapy (ICT), which mainly reactivates existing tumor-specific T cells together with T cells of unknown specificities. To decrease the activation of non-tumor-specific T cells, active or passive immunizations against tumor-specific antigens are considered. These immunizations require the identification of at least some of the tumor-specific antigens displayed on the tumor cells of a patient. While this has become an easy task for tumors with a large number of mutations generating neoantigens, it remains difficult for the remainder. Here, we review some facts about human tumor-specific or tumor-associated antigens, as well as some hopes for their future use in cancer immunotherapy.
ISSN:1078-0432
1557-3265
DOI:10.1158/1078-0432.CCR-21-3798