Morin attenuates neurobehavioural deficits, hippocampal oxidative stress, inflammation, and apoptosis in rats co-exposed to bisphenol S and diethyl phthalate

[Display omitted] •A mixture of bisphenol S and diethyl phthalate (MBD) induced neurotoxic outcomes.•These outcomes were similar to those previously reported for their predecessors.•Morin protected against attendant behavioural and neurosignalling deficits.•Morin attenuated hippocampal oxidative str...

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Published in:Brain research 2022-11, Vol.1794, p.148068-148068, Article 148068
Main Authors: Ugwor, Emmanuel Ifeanyichukwu, Dosumu, Oluwatosin Adebisi, Eteng, Ofem Effiom, Moses, Ceaser Antiya, Ogbonna, Chukwuka Uzoamaka, James, Adewale Segun, Adeleye, Abdulwasiu Oladokun, Ilavbarhe, Mohammed Emmanuel, Ajasa, Florence, Olawuyi, Oluwakemi, Ugbaja, Regina Ngozi
Format: Article
Language:English
Subjects:
Bisphenol S
Diethyl phthalate
Hippocampus
Morin
Neurotoxicity
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Summary:[Display omitted] •A mixture of bisphenol S and diethyl phthalate (MBD) induced neurotoxic outcomes.•These outcomes were similar to those previously reported for their predecessors.•Morin protected against attendant behavioural and neurosignalling deficits.•Morin attenuated hippocampal oxidative stress in MBD-exposed rats.•Morin suppressed hippocampal inflammation and apoptosis. Endocrine-disrupting pollutants (EDPs) remain pervasive in the environment. Bisphenol S (BPS) and diethyl phthalates (DEP) are commonly used to replace the more toxic EDPs. However, it is unclear if they induce neurotoxicity, like their predecessors. Morin possesses relevant neuro-pharmacological activities. Hence, we sought to evaluate the protective effects of morin against the neurotoxic effects previously reported for EDPs. Male Wistar rats were exposed to a mixture of BPS and DEP (MBD) and treated with morin for 21 days. Behavioural assessments were conducted, and the hippocampal tissues were processed for analysis. Rats exposed to MBD presented anxiety-like behaviours, impaired cognitive and motor functions compared to the control group. MBD exposure induced hyperactivity of neurosignalling enzymes (AChE, ADA, MAO-A) and depleted hippocampal antioxidants (SOD, CAT, GPx, and GSH). MBD exposure increased calcium levels and inhibited total Ca2+-ATPase activity. Levels of reactive species (NO and H2O2) and oxidative damage markers (MDA and AOPP) were significantly (P 
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2022.148068