Chromium picolinate supplementation improves cardiac performance in hypoxic rats

• Published in: Acta Cardiologica 2024-05, Vol.ahead-of-print (ahead-of-print), p.1-11
• Main Author: Abdel-Hady, Enas A.
• Format: Article
• Language: English
• Subjects: Animals; Antioxidants - pharmacology; Cardioprotection; chromium; chronic intermittent hypoxia; Dietary Supplements; Disease Models, Animal; Heart Rate - drug effects; Hypoxia - complications; Hypoxia - physiopathology; ischaemia/reperfusion; Male; Myocardium - metabolism; Oxidative Stress - drug effects; Picolinic Acids - pharmacology; Rats; Rats, Wistar
• ISSN: 0001-5385; 1784-973X; 0373-7934
• DOI: 10.1080/00015385.2022.2041782

Conditions associated with chronic hypoxia increase morbidity and mortality attributable to cardiovascular complications. Myocardial hypoxia is a common feature in several diseases including: stroke, infarction, anaemia, chronic lung diseases, obstructive sleep apnoea and cyanotic congenital heart defects. The present study was planned to investigate the cardiovascular effects of chronic intermittent hypoxia and its association with increased myocardial oxidative stress. In addition, to evaluate the protective effect of chromium supplementation, aiming at achieving an alternative that may enable to devise a therapy for hypoxic patients. Male rats were allocated into three groups: control group (normoxic), untreated hypoxic group (exposed to hypoxia 8 h/day, 5 days/week for 6 weeks) and hypoxic group supplemented with chromium picolinate (90 µg/kg/day by gavage). Rats were subjected to measurement of body weight, haematocrit value, mean arterial blood pressure, heart rate and ECG recording. Cardiac activities of isolated hearts were studied on Langendorff preparation under basal conditions and in response to ischaemia/reperfusion. Thereafter, cardiac weights were determined and cardiac tissue catalase activity as well as malondialdhyde level were assessed. Significant results were obtained upon exposure to hypoxia including; low body weight, increased haematocrit, elevated blood pressure, left ventricular hypertrophy and impaired cardiac activities, basally and in response to ischaemia/reperfusion challenges, associated with increased oxidative stress in cardiac tissue. At the same time, chromium supplementation increased body weight, lowered blood pressure, reduced ventricular hypertrophy and significantly improved the cardiac performance. Chromium supplementation confers protection against hypoxia-induced cardiovascular dysfunction by improvement of the antioxidant capacity.