Neuroprotective Effects of Probiotic Lactobacillus reuteri GMNL-263 in the Hippocampus of Streptozotocin-Induced Diabetic Rats

Diabetes-related brain complications have been reported in clinical patients and experimental models. The objective of the present study was to investigate the neuroprotective mechanisms of Lactobacillus reuteri GMNL-263 in streptozotocin (STZ)-induced diabetic rats. In this study, three different g...

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Published in:Probiotics and antimicrobial proteins 2023-10, Vol.15 (5), p.1287-1297
Main Authors: Lin, Jing-Ying, Tsai, Bruce Chi-Kang, Kao, Hui-Chuan, Chiang, Chien-Yi, Chen, Yun-An, Chen, William Shao-Tsu, Ho, Tsung-Jung, Yao, Chun-Hsu, Kuo, Wei-Wen, Huang, Chih-Yang
Format: Article
Language:English
Subjects:
Apoptosis
Applied Microbiology
Biomedical and Life Sciences
Cell survival
Chemistry/Food Science
Diabetes
Diabetes mellitus
Hippocampus
Inflammation
Lactobacillus reuteri
Life Sciences
Microbiology
Neuroprotection
Nutrition
Probiotics
Protein Science
Signal transduction
Streptozocin
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Summary:Diabetes-related brain complications have been reported in clinical patients and experimental models. The objective of the present study was to investigate the neuroprotective mechanisms of Lactobacillus reuteri GMNL-263 in streptozotocin (STZ)-induced diabetic rats. In this study, three different groups, namely control group, STZ-induced (55 mg/kg streptozotocin intraperitoneally) diabetic rats (DM), and DM rats treated with Lactobacillus reuteri GMNL-263 (1 × 10 9  CFU/rat/day), were utilized to study the protective effect of GMNL-263 in the hippocampus of STZ-induced diabetic rats. The results demonstrated that GMNL-263 attenuated diabetes-induced hippocampal damage by enhancing the cell survival pathways and repressing both inflammatory and apoptotic pathways. Histopathological analysis revealed that GMNL-263 prevented structural changes in the hippocampus in the DM group and decreased the level of inflammation and apoptosis in the hippocampus of DM rats. The IGF1R cell survival signaling pathway also improved after GMNL-263 treatment. These results indicate that probiotic GMNL-263 exerts beneficial effects in the brain of diabetic rats and has potential ability for clinical application. Graphical abstract
ISSN:1867-1306
1867-1314
DOI:10.1007/s12602-022-09982-w