Gold nanoparticles bearing a clinically used non-antibiotic drug for combating multi-drug resistant bacteria

We introduce N -acetyl- l -cysteine (NAC), a clinically used non-antibiotic drug, to the synthesis of antibacterial gold nanoparticles (Au_NAC). Au_NAC shows excellent antibacterial activities against multi-drug resistant (MDR) Gram-negative bacteria and possesses wound healing capabilities. We prov...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2022-09, Vol.58 (75), p.1544-1547
Main Authors: Jia, Yuexiao, Zhang, Jiangjiang, Zhao, Yingcan, Dong, Ruihua, Wang, Hui, Jiang, Xingyu
Format: Article
Language:English
Subjects:
Antibiotics
Bacteria
Gold
Nanoparticles
Wound healing
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Summary:We introduce N -acetyl- l -cysteine (NAC), a clinically used non-antibiotic drug, to the synthesis of antibacterial gold nanoparticles (Au_NAC). Au_NAC shows excellent antibacterial activities against multi-drug resistant (MDR) Gram-negative bacteria and possesses wound healing capabilities. We provide a new direction for antibiotic design and novel uses of known drugs. We introduce a clinically used non-antibiotic drug, N -acetyl- l -cysteine (NAC), to the synthesis of a new antimicrobial (Au_NAC) against multi-drug resistant Gram-negative bacteria by presenting it on gold nanoparticles (Au NPs).
ISSN:1359-7345
1364-548X
DOI:10.1039/d2cc03460c