Reductive-Delay Heck 1,1-Diarylation of Terminal Alkenes

Pd-catalyzed chemo- and regiocontrollable 1,1-diarylation of unactivated aliphatic alkenes with two aryl halides was developed. Under the cationic reductive-delay Heck pathway, the first aryl insertion is followed by β-H elimination, while the second aryl insertion is terminated by C–H bond formatio...

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Bibliographic Details
Published in:Organic letters 2022-09, Vol.24 (36), p.6520-6524
Main Authors: Shao, Huihui, Zhao, Yao, Wang, Shuangqiang, Chen, Rizhi, Zhou, Jianrong Steve, Wu, Xiaojin
Format: Article
Language:English
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Summary:Pd-catalyzed chemo- and regiocontrollable 1,1-diarylation of unactivated aliphatic alkenes with two aryl halides was developed. Under the cationic reductive-delay Heck pathway, the first aryl insertion is followed by β-H elimination, while the second aryl insertion is terminated by C–H bond formation.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.2c02416