Porous hydroxyapatite-dodecylphosphate composite film on titania-titanium substrate

• Published in: Journal of materials chemistry 1999, Vol.9 (3), p.703-710
• Main Authors: SOTEN, I, OZIN, G. A
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Cross-disciplinary physics: materials science; rheology; Exact sciences and technology; Liquid phase epitaxy; deposition from liquid phases (melts, solutions, and surface layers on liquids); Materials science; Medical sciences; Methods of deposition of films and coatings; film growth and epitaxy; Physics; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Technology. Biomaterials. Equipments
• ISSN: 0959-9428; 1364-5501
• DOI: 10.1039/a806045b

Synthetic analogues of bone are being actively pursued as materials for biomedical applications in the field of bone replacement, augmentation and repair. Numerous stringent criteria have to be met for a biomaterial to be considered as an acceptable bone implant, including the ability to integrate into bone and not cause any deleterious side effects. A materials chemistry approach to synthesising a new type of bone implant material is described. The strategy involves the spontaneous growth, under aqueous physiological pH conditions, of an oriented hydroxyapatite film with micron-sized pores, on the surface of a TiO2 layer sputter deposited on Ti metal. This procedure creates desirable co-crystallised phases of HAp and octacalcium phosphate (OCP) with preferred orientation respectively along the 001 and 101 axis directions. Subsequently, a calcium dodecylphosphate mesolamellar phase was grown within these oriented porous films to create a multilayered chemical composite CaDDP-OHAp-TiO2-Ti in which the CaDDP phase is stereochemically and charge matched with the OHAp. 29 refs.