Karnofsky performance status and visual analogue scale scores are simple indicators for quality of life in long-term AYA survivors who received allogeneic hematopoietic stem cells transplantation in childhood

The purpose of this study was to investigate Karnofsky performance status (KPS) scores and visual analogue scale (VAS) scores to explain which domains in the standardized self-reported quality of life (QOL) are instrumental for long-term hematopoietic stem cell transplantation (HSCT) survivors. We c...

Full description

Saved in:
Bibliographic Details
Published in:International journal of hematology 2022-11, Vol.116 (5), p.787-797
Main Authors: Ishida, Yasushi, Kamibeppu, Kiyoko, Sato, Atsushi, Inoue, Masami, Hayakawa, Akira, Shiobara, Masaaki, Yabe, Hiromasa, Koike, Kazutoshi, Adachi, Soichi, Yamashita, Takuya, Kanda, Yoshinobu, Okamoto, Shinichiro, Atsuta, Yoshiko
Format: Article
Language:English
Subjects:
Bone cancer
Bone marrow
Bone marrow transplantation
Cancer therapies
Childhood
Children
Correlation
Health problems
Hematology
Hematopoietic stem cells
Medicine
Medicine & Public Health
Mental disorders
Oncology
Original Article
Pediatrics
Quality of life
Stem cell transplantation
Stem cells
Survival
Transplantation
Transplants & implants
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The purpose of this study was to investigate Karnofsky performance status (KPS) scores and visual analogue scale (VAS) scores to explain which domains in the standardized self-reported quality of life (QOL) are instrumental for long-term hematopoietic stem cell transplantation (HSCT) survivors. We conducted a nationwide cross-sectional questionnaire study on 221 survivors with allogeneic-HSCT in 28 pediatric centers. Patient-reported QOL was assessed at a single time point using the 36-item Short-Form Survey (SF-36), the Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT), and VAS scores. KPS scores were significantly correlated with both physical and role component summary scores of the SF-36, while the VAS provided by the patient (VASpt) was significantly correlated with the mental component summary score of the SF-36 and many subscales of the FACT-BMT. The VAS provided by the participants’ attending physician (VASdoc) was correlated well with KPS scores. A VASpt score more than 40% lower than KPS scores suggested mental health problems. In conclusion, KPS scores might be considered as an indicator for physical and role/social components and VASpt score as an indicator for mental components and HSCT-specific QOL.
ISSN:0925-5710
1865-3774
DOI:10.1007/s12185-022-03426-5