Specific Antibodies to the Fragments of Meningococcal IgA1 Protease during the Formation of Immunity to Bacterial Infections

The features of individual fragments of IgA1 protease of Neisseria meningitidis serogroup B during the formation of immunity to bacterial infections in animals and humans were studied. The antibodies to the immunogenic regions of the studied proteins are also detected in mice infected with some bact...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2022-08, Vol.173 (4), p.429-432
Main Authors: Kotel’nikova, O. V., Prokopenko, Yu. A., Zinchenko, A. A., Razgulyaeva, O. A., Nokel’, E. A., Karlinsky, D. M., Zhigis, L. S., Rumsh, L. D.
Format: Article
Language:English
Subjects:
Animals
Antibodies
Bacteria
Bacterial infections
Biomedical and Life Sciences
Biomedicine
Cell Biology
Enzymes
Health aspects
Immune response
Immunity
Immunization
Immunogenicity
Immunoglobulin A
Immunology
Immunology and Microbiology
Internal Medicine
Laboratory Medicine
Medical research
Medicine, Experimental
Meningitis
Molecular weight
Pathogens
Pathology
Proteases
Proteinase
Proteins
Recombinant proteins
Streptococcus infections
Virulence
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Summary:The features of individual fragments of IgA1 protease of Neisseria meningitidis serogroup B during the formation of immunity to bacterial infections in animals and humans were studied. The antibodies to the immunogenic regions of the studied proteins are also detected in mice infected with some bacterial pathogens and in humans with bacterial meningitis. A region of IgA1 protease was identified that is not capable of producing antibodies during immunization of animals, but that detects homologous antibodies in the blood of humans and animals recovered from bacterial infections. It has been suggested that this fragment plays a regulatory role in the process of immunogenesis.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-022-05580-6