Autophagy in Human Retinal Neurons in Glaucoma

Immunohistochemical and ultrastructural analysis revealed signs of structural alterations in neurons and autophagy in all layers of the human retina at the end-stage glaucoma. The most pronounced destructive changes associated with swelling and destruction of mitochondria, endoplasmic reticulum, and...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2022-08, Vol.173 (4), p.468-474
Main Authors: Obanina, N. A., Bgatova, N. P., Eremina, A. V., Trunov, A. N., Chernykh, V. V.
Format: Article
Language:English
Subjects:
Analysis
Apoptosis
Autophagy
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cones
Endoplasmic reticulum
Glaucoma
Golgi apparatus
Homeostasis
Internal Medicine
Laboratory Medicine
Melanoma
Microscopy
Microsurgery
Mitochondria
Morphology and Pathomorphology
Neurodegeneration
Neurons
Optic nerve
Organelles
Oxidative stress
Pathology
Retina
Software
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Summary:Immunohistochemical and ultrastructural analysis revealed signs of structural alterations in neurons and autophagy in all layers of the human retina at the end-stage glaucoma. The most pronounced destructive changes associated with swelling and destruction of mitochondria, endoplasmic reticulum, and Golgi apparatus, as well as structural signs of impaired synaptic activity and apoptosis were noted in ganglion, bipolar, and amacrine neurons. In the structure of photoreceptor cells, alone with destructive processes associated with structural alterations of rods and cones in the outer membrane discs, as well as swelling of organelles, we observed processes aimed at the maintenance of cell homeostasis. Structural signs of autophagy (mainly mitophagy) and changes of the ultrastructural organization in rod neurons were more pronounced than in cones.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-022-05563-7