Association between fat mass and mortality: analysis of Mendelian randomization and lifestyle modification

The association between fat mass and mortality has been equivocally shown to be linear, J-shaped, and U-shaped. We aimed to clarify this relationship based on Mendelian randomization (MR) analysis and lifestyle modification. This prospective analysis included 449,831 participants from UK Biobank. Li...

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Published in:Metabolism, clinical and experimental clinical and experimental, 2022-11, Vol.136, p.155307-155307, Article 155307
Main Authors: Hu, Jinbo, Chen, Xiangjun, Yang, Jun, Giovannucci, Edward, Lee, Dong Hoon, Luo, Wenjin, Cheng, Qingfeng, Gong, Lilin, Wang, Zhihong, Li, Qifu, Yang, Shumin
Format: Article
Language:English
Subjects:
Anthropometry
Body Mass Index
Diet
Fat mass
Humans
Life Style
Lifestyle modification
Mendelian randomization
Mendelian Randomization Analysis
Mortality
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Summary:The association between fat mass and mortality has been equivocally shown to be linear, J-shaped, and U-shaped. We aimed to clarify this relationship based on Mendelian randomization (MR) analysis and lifestyle modification. This prospective analysis included 449,831 participants from UK Biobank. Linear MR analysis was used to estimate the linear relationship between fat mass and mortality. We assessed whole body fat mass by bioimpedance analysis at baseline and categorized subjects into five equal groups based on fat mass index (FMI). The association between FMI and mortality were investigated among whole population and in subgroups stratified by individual lifestyle factors, including diet, physical activity, smoking, alcohol, sleep and psychological health. Linear MR analyses indicated a positive association between genetically predicted fat mass and all-cause mortality (HR 1.10, 95 % CI 1.08–1.12, P 
ISSN:0026-0495
1532-8600
DOI:10.1016/j.metabol.2022.155307