Locoregional relapse after sparing mastectomies and immediate reconstruction in women with breast cancer

• Published in: Cirugia española (English ed.) 2023-02, Vol.101 (2), p.97-106
• Main Authors: Acea-Nebril, Benigno, García-Novoa, Alejandra, Díaz, Mónica Torres, Alejandro, Alberto Bouzón, Carballada, Carlota Díaz, Conde Iglesias, Carmen, Díaz Martínez, Inmaculada, Martínez Arribas, Carme, Calvo Martínez, Lourdes, Novoa, Silvia Antolin, Santiago Freijanes, Paz, Oses, Joaquín Mosquera
• Format: Article
• Language: English
• Subjects: Breast Neoplasms - pathology; Breast Neoplasms - surgery; Female; Humans; Immediate reconstruction; Locoregional relapse; Lymph node relapse; Mammaplasty - methods; Mastectomy - methods; Mastectomía preservadora de piel; Mastectomía preservadora de piel y pezón; Neoplasm Recurrence, Local - epidemiology; Neoplasm Recurrence, Local - pathology; Neoplasm Recurrence, Local - surgery; Nipple-skin sparing mastectomy; Prospective Studies; Recaída ganglionar; Recaída locorregional; Reconstrucción inmediata; Recurrence; Skin sparing mastectomy
• ISSN: 2173-5077; 2173-5077
• DOI: 10.1016/j.cireng.2022.09.007

[Display omitted] In recent years, cultural changes in today's society and improved risk assessment have increased the indication for mastectomies in women with breast cancer. Various studies have confirmed the oncological safety of sparing mastectomies and immediate reconstruction. The objective of this study is to analyze the incidence of locoregional relapses of this procedure and its impact on reconstruction and overall survival. Prospective study of patients with breast carcinoma who underwent a sparing mastectomy and immediate reconstruction. Locoregional relapses and their treatment and their impact on survival were analyzed. The study group is made up of 271 women with breast carcinoma treated with a skin-sparing mastectomy and immediate reconstruction. The mean follow-up was 7.98 years and during the same 18 locoregional relapses (6.6%) were diagnosed: 72.2% in the mastectomy flap and 27.8% lymph node. There were no significant differences in the pathological characteristics of the primary tumor between patients with and without locoregional relapse, although the percentage of women with hormone-sensitive tumors was higher in the group without relapse. Patients with lymph node relapse had larger tumors (80% T2-T3) and 60% had axillary metastases at diagnosis, compared to 7.7% of women with skin relapse (p = 0.047). All patients operated on for locoregional relapse preserved their reconstruction. The incidence of metastases and deaths was significantly higher in patients with a relapse, causing a non-significant decrease in overall survival. Locoregional relapses are a rare event in women with a sparing mastectomy and immediate reconstruction. Most patients with locoregional relapse can preserve their initial reconstruction through local resection of the tumor and adjuvant and / or neoadjuvant therapies. Durante los últimos años los cambios culturales de la sociedad actual y la mejora en la valoración del riesgo han incrementado la indicación de las mastectomías en mujeres con cáncer de mama. Diversos estudios han confirmado la seguridad oncológica de la mastectomías preservadoras y reconstrucción inmediata. El objetivo de este estudio es analizar la incidencia de recaídas locorregionales de este procedimiento y su impacto en la reconstrucción y la supervivencia global. Estudio prospectivo de pacientes con un carcinoma de mama que realizaron una mastectomía preservadora y reconstrucción inmediata. Se analizaron las recaídas locorregionales, el trat