Pectin functionalized metal-organic frameworks as dual-stimuli-responsive carriers to improve the pesticide targeting and reduce environmental risks

• Published in: Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2022-11, Vol.219, p.112796, Article 112796
• Main Authors: Liang, You, Wang, Sijin, Jia, Huijuan, Yao, Yijia, Song, Jiehui, Dong, Hongqiang, Cao, Yongsong, Zhu, Feng, Huo, Zhongyang
• Format: Article
• Language: English
• Subjects: Animals; Biological safety; Dual-responsive; Magnaporthe oryzae; Metal-organic frameworks; Metal-Organic Frameworks - chemistry; Metal-Organic Frameworks - pharmacology; Nanoparticles - chemistry; Pectin; Pectins - chemistry; Pesticides - chemistry; Pesticides - pharmacology; Zebrafish
• ISSN: 0927-7765; 1873-4367; 1873-4367
• DOI: 10.1016/j.colsurfb.2022.112796

Encapsulation of active ingredients into intelligent response controlled release carriers has been recognized as a promising approach to enhance the utilization efficiency and reduce the environmental risks of pesticides. In this work, an intelligent redox and pectinase dual stimuli-responsive pesticide delivery system was constructed by bonding pectin with metal-organic frameworks (FeMOF nanoparticles) which were loaded with pyraclostrobin (PYR@FeMOF-pectin nanoparticles). The successful fabrication of PYR@FeMOF-pectin nanoparticles was proved by a series of physicochemical characterizations. The results indicated that the loading capacity of PYR@FeMOF-pectin nanoparticles for pyraclostrobin was approximately 20.6%. The pectin covered on the surface of PYR@FeMOF nanoparticles could protect pyraclostrobin from photolysis and improve their spreadability on rice blades effectively. Different biological stimuli associated with Magnaporthe oryzae could trigger the release of pyraclostrobin from the pesticide-loaded core-shell nanoparticles, resulting in the death of pathogens. The bioactivity survey determined that PYR@FeMOF-pectin nanoparticles had a superior fungicidal activity and a longer duration against Magnaporthe oryzae than pyraclostrobin suspension concentrate. In addition, the FeMOF-pectin nanocarriers showed no obvious phytotoxicity and could enhance the shoot length and root length of rice plants. More importantly, PYR@FeMOF-pectin nanoparticles had an 8-fold reduction in acute toxicity to zebrafish than that of pyraclostrobin suspension concentrate. Therefore, the dual-responsive FeMOF-pectin nanocarriers have great potential for realizing site-specific pesticide delivery and promoting plant growth. [Display omitted] •A smart redox/pectinase dual-responsive pesticide delivery system was established.•PYR@FeMOF-pectin nanoparticles could protect pyraclostrobin from photodegradation.•PYR@FeMOF-pectin nanoparticles had a long duration against Magnaporthe oryzae.•The system would reduce the threats of pyraclostrobin to aquatic organisms.