Novel model for chronic intestinal inflammation in chickens: (2) Immunologic mechanism behind the inflammatory response

Intestinal inflammation in poultry is a complex response that involves immune and intestinal cells which is still not fully understood. Thus, to better understand the mechanisms that drive the chronic intestinal inflammation in fowl we conducted an experiment applying a previously established nutrit...

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Bibliographic Details
Published in:Developmental and comparative immunology 2023-01, Vol.138, p.104524-104524, Article 104524
Main Authors: Cardoso Dal Pont, Gabriela, Lee, A., Bortoluzzi, C., Farnell, Y.Z., Gougoulias, C., Kogut, M.H.
Format: Article
Language:English
Subjects:
adaptive immunity
Broiler
broiler chickens
chemokines
Chronic inflammation
diet
histology
ileum
inflammation
interferon-alpha
Interleukin
interleukin-10
interleukin-21
interleukin-6
Intestinal inflammation
jejunum
monocytes
Mucosal immune system
polysaccharides
T-cell
T-lymphocytes
vascular endothelial growth factors
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Summary:Intestinal inflammation in poultry is a complex response that involves immune and intestinal cells which is still not fully understood. Thus, to better understand the mechanisms that drive the chronic intestinal inflammation in fowl we conducted an experiment applying a previously established nutritional model of low-grade chronic intestinal inflammation to evaluate cytokine and chemokine profiles in the chicken intestine. For this, we placed 90 one-day chickens into two treatments: (1) a control group (CNT) fed a corn-soybean diet, and (2) a group fed a diet high in non-starch polysaccharides (NSP). At days 14, 22, 28 and 36 of age, 6 birds from each treatment were euthanized, jejunal and ileal samples were collected for histological examination and cytokine measurements. The cytokines interferon-alpha (IFN-α), IFN-γ, interleukin-16 (IL-16), IL-10, IL-21, IL-6, macrophage-colony stimulating factor (M-CSF), chemokine C–C motif ligand 20 (CCL20), CCL4, CCL5 and vascular endothelial growth factor (VEGF) were quantified in the intestinal tissue. Histologically, both jejunum and ileum of broilers fed NSP diet showed marked infiltration of mononuclear immune cells into the villi. Further, these birds exhibited a significant (P 
ISSN:0145-305X
1879-0089
DOI:10.1016/j.dci.2022.104524