Epstein-Barr virus central nervous system involvement in Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis

Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) is a common subtype of secondary HLH. EBV plays an important part in the course. EBV can cause central nervous system (CNS) infections, and there are few clinical studies on EBV-CNS infection in EBV-HLH patients. All patients...

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Bibliographic Details
Published in:Annals of hematology 2022-11, Vol.101 (11), p.2471-2476
Main Authors: Yin, Qingxia, Wang, Jingshi, Wang, Zhao
Format: Article
Language:English
Subjects:
Cerebrospinal fluid
Epstein-Barr virus
Hematology
Infections
Lymphatic diseases
Medical prognosis
Medicine
Medicine & Public Health
Nervous system
Oncology
Original Article
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Summary:Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) is a common subtype of secondary HLH. EBV plays an important part in the course. EBV can cause central nervous system (CNS) infections, and there are few clinical studies on EBV-CNS infection in EBV-HLH patients. All patients who were diagnosed as EBV-HLH and underwent cerebrospinal fluid testing admitted to our center from January 2018 to December 2019 were retrospectively analyzed. Summarized the clinical data, evaluated treatment efficacy after intrathecal injection, and investigated the correlation between EBV-CNS infection with prognosis in EBV-HLH patients. Of 37 of 57 (64.9%) EBV-HLH patients has EBV-CNS infection. The survival of EBV-HLH patients without EBV-CNS infection was significantly better than that in EBV-CNS infection patients ( P  = 0.018). There were no statistically significant differences in sCD25, ferritin, ALT, AST, LDH, TB, WBC, Hb, and PLT counts between two groups (all P -values > 0.05). Higher EBV-DNA load in peripheral blood was correlated with EBV-CNS infection ( P  
ISSN:0939-5555
1432-0584
DOI:10.1007/s00277-022-04957-x