Bioactive extracellular matrix fragments in tendon repair

Tendinopathy is a common tendon disorder that causes pain, loss of strength and function, and local inflammation mainly characterized by hypoxia, collagen degradation, and extracellular matrix (ECM) disorganization. Generally, ECM degradation and remodeling is tightly regulated; however, hyperactiva...

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Bibliographic Details
Published in:Cell and tissue research 2022-11, Vol.390 (2), p.131-140
Main Authors: Mohindra, Ritika, Mohindra, Rohit, Agrawal, Devendra K., Thankam, Finosh G.
Format: Article
Language:English
Subjects:
Aprotinin
Biomedical and Life Sciences
Biomedicine
Cell proliferation
Collagen
Degradation
Extracellular matrix
Fibroblasts
Human Genetics
Hyaluronic acid
Hypoxia
Inflammation
Injuries
Molecular Medicine
Pathogenesis
Pathology
Peptides
Physiology
Proteases
Proteins
Proteomics
Review
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Description
Summary:Tendinopathy is a common tendon disorder that causes pain, loss of strength and function, and local inflammation mainly characterized by hypoxia, collagen degradation, and extracellular matrix (ECM) disorganization. Generally, ECM degradation and remodeling is tightly regulated; however, hyperactivation of matrix metalloproteases (MMPs) contributes to excessive collagenolysis under pathologic conditions resulting in tendon ECM degradation. This review article focuses on the production, function, and signaling of matrikines for tendon regeneration following injury with insights into the expression, tissue compliance, and cell proliferation exhibited by various matrikines. Furthermore, the regenerative properties suggest translational significance of matrikines to improve the outcomes post-injury by assisting with tendon healing.
ISSN:0302-766X
1432-0878
DOI:10.1007/s00441-022-03684-z