Regional variation in the incidence of pseudo-exfoliation in the Andhra Pradesh Eye Disease Study (APEDS)

• Published in: Eye (London) 2023-06, Vol.37 (8), p.1704-1710
• Main Authors: Choudhari, Nikhil S., Khanna, Rohit C., Marmamula, Srinivas, Mettla, Asha Latha, Giridhar, Pyda, Banerjee, Seema, Shekhar, Konegari, Chakrabarti, Subhabrata, Murthy, Gudlavalleti V. S., Gilbert, Clare, Rao, Gullapalli N.
• Format: Article
• Language: English
• Subjects: 692/308/174; 692/700/478/174; Adult; Age; Exfoliation; Exfoliation Syndrome - complications; Eye diseases; Female; Glaucoma; Glaucoma - complications; Glaucoma - diagnosis; Glaucoma - epidemiology; Humans; Incidence; Intraocular Pressure; Laboratory Medicine; Longitudinal Studies; Male; Medicine; Medicine & Public Health; Ophthalmology; Pharmaceutical Sciences/Technology; Population studies; Surgery; Surgical Oncology; Variation
• ISSN: 0950-222X; 1476-5454
• DOI: 10.1038/s41433-022-02226-9

Background To report the 15-year incidence rate of pseudo-exfoliation (PXF),  PXF glaucoma and regional variation among rural participants in the Andhra Pradesh Eye Disease Study (APEDS) III. Methods This population-based longitudinal study was carried out at three rural study sites. Individuals of all ages who participated at baseline with a mean 15-year follow-up visit were included. Detailed Comprehensive ophthalmic examination was performed on all participants. The main outcome measure was development of PXF during the follow-up period in participants who were phakic in one or both eyes without PXF at baseline. Results Among 5395 participants, 5108 (94.6%) met the inclusion criteria. There were 93 (1.82%; 95% confidence interval (CI), 1.47–2.22) cases of incident PXF. Their median baseline age (1st, 3rd quartiles) was 51 (44, 59) years and the male: female ratio was 1.3:1. There was no case of incident PXF in participants aged