Thrombin generation potential is increased in patients with autoimmune inflammatory myopathies

Dermatomyositis and polymyositis (DM/PM) are rare autoimmune inflammatory myopathies, characterized by an increased risk of cardiovascular and thromboembolic events, likely related to the prothrombotic plasma properties. The aim of this study was to assess the in vitro thrombin generation profile as...

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Bibliographic Details
Published in:Advances in medical sciences 2022-09, Vol.67 (2), p.346-352
Main Authors: Kuszmiersz, Piotr, Siwiec-Koźlik, Andżelika, Pacholczak-Madej, Renata, Rams, Anna, Celińska-Lowenhoff, Magdalena, Iwaniec, Teresa, Kosałka-Węgiel, Joanna, Zaręba, Lech, Dziedzic, Radosław, Bazan-Socha, Stanisława, Dropiński, Jerzy
Format: Article
Language:English
Subjects:
Dermatomyositis
Polymyositis
Thrombin generation
Thrombosis
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Summary:Dermatomyositis and polymyositis (DM/PM) are rare autoimmune inflammatory myopathies, characterized by an increased risk of cardiovascular and thromboembolic events, likely related to the prothrombotic plasma properties. The aim of this study was to assess the in vitro thrombin generation profile as a biomarker of plasma procoagulant properties in DM/PM patients. In 58 clinically stable DM/PM patients and 67 controls matched for sex, age, body mass index, we measured plasma thrombin generation potential using the Calibrated Automated Thrombinography (CAT) and analyzed its relationship with clinical disease characteristics, including autoantibodies profile. Patients with DM/PM had a 21% increase in endogenous thrombin potential (ETP), 36% higher peak thrombin concentration, and 11% faster thrombin generation, compared to controls (p ​
ISSN:1896-1126
1898-4002
DOI:10.1016/j.advms.2022.08.005