An in silico analysis revealed a novel evolutionary lineage of putative mitoviruses

Mitoviruses (family Mitoviridae) are small capsid‐less RNA viruses that replicate in the mitochondria of fungi and plants. However, to date, the only authentic animal mitovirus infecting an insect was identified as Lutzomyia longipalpis mitovirus 1 (LulMV1). Public databases of transcriptomic studie...

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Published in:Environmental microbiology 2022-12, Vol.24 (12), p.6463-6475
Main Authors: Jacquat, Andrés Gustavo, Ulla, Sofía Belén, Debat, Humberto Julio, Muñoz‐Adalia, Emigdio Jordán, Theumer, Martín Gustavo, Pedrajas, María Dolores García, Dambolena, José Sebastián
Format: Article
Language:English
Subjects:
Animals
Aquatic crustaceans
Arachnids
Crustaceans
Fungi
Genome, Viral
Identification
Insects
Libraries
Marine invertebrates
Maximum likelihood method
Mitochondria
Mitochondria - genetics
NR protein
Phylogenetics
Phylogeny
Plant Diseases - microbiology
Proteins
RNA viruses
RNA Viruses - genetics
RNA, Viral
Sequences
Shotguns
Transcriptomes
Transcriptomics
Viruses
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Summary:Mitoviruses (family Mitoviridae) are small capsid‐less RNA viruses that replicate in the mitochondria of fungi and plants. However, to date, the only authentic animal mitovirus infecting an insect was identified as Lutzomyia longipalpis mitovirus 1 (LulMV1). Public databases of transcriptomic studies from several animals may be a good source for identifying the often missed mitoviruses. Consequently, a search of mitovirus‐like transcripts at the NCBI transcriptome shotgun assembly (TSA) library, and a search for the mitoviruses previously recorded at the NCBI non‐redundant (nr) protein sequences library, were performed in order to identify new mitovirus‐like sequences associated with animals. In total, 10 new putative mitoviruses were identified in the TSA database and 8 putative mitoviruses in the nr protein database. To our knowledge, these results represent the first evidence of putative mitoviruses associated with poriferan, cnidarians, echinoderms, crustaceans, myriapods and arachnids. According to different phylogenetic inferences using the maximum likelihood method, these 18 putative mitoviruses form a robust monophyletic lineage with LulMV1, the only known animal‐infecting mitovirus. These findings based on in silico procedures provide strong evidence for the existence of a clade of putative mitoviruses associated with animals, which has been provisionally named ‘kvinmitovirus’.
ISSN:1462-2912
1462-2920
DOI:10.1111/1462-2920.16202