Diffuse Reflectance Spectroscopy for The Assessment of Steatosis in Liver Phantom and Liver Donors - A Pilot Study

This paper reports the application of a low-cost diagnostic modality for fat analysis in a liver phantom as well as human liver donors. The device works on the principle of diffuse reflectance spectroscopy, which absorbs and/or scatters depending upon the molecules that compose a tissue. Here, we de...

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Bibliographic Details
Main Authors: Rajamani, Allwyn S., Shamlee, J. Kuzhandai, Rammohan, Ashwin, Sai, V.V.R., Rela, Mohamed
Format: Conference Proceeding
Language:English
Subjects:
Biopsy
Liver
Phantoms
Real-time systems
Reflectivity
Spectroscopy
Surgery
Online Access:Request full text
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Summary:This paper reports the application of a low-cost diagnostic modality for fat analysis in a liver phantom as well as human liver donors. The device works on the principle of diffuse reflectance spectroscopy, which absorbs and/or scatters depending upon the molecules that compose a tissue. Here, we describe the development of liver phantom of varying fat concentration using saturated fat mimicking liver steatosis. Followed by a pilot study in the human liver donor setting. Later, handheld device based on Infrared-LED and Photodetector for real-time time assessment of live donor liver and fat assessment. Clinical Relevance- This device can be used in the development of an accurate and non-invasive for quantification of liver fat in the deceased donor selection process. It has an error margin of 10% in the quantification of fat which is comparable to a standard biopsy technique
ISSN:2694-0604
DOI:10.1109/EMBC48229.2022.9871515