Alginate based hydrogel inks for 3D bioprinting of engineered orthopedic tissues

3D printed hydrogels have emerged as a novel tissue engineering and regeneration platform due to their ability to provide a suitable environment for cell growth. To obtain a well-defined scaffold with good post-printing shape fidelity, a proper hydrogel ink formulation plays a crucial role. In this...

Full description

Saved in:
Bibliographic Details
Published in:Carbohydrate polymers 2022-11, Vol.296, p.119964-119964, Article 119964
Main Authors: Murab, Sumit, Gupta, Aastha, Włodarczyk-Biegun, Małgorzata Katarzyna, Kumar, Anuj, van Rijn, Patrick, Whitlock, Patrick, Han, Sung Soo, Agrawal, Garima
Format: Article
Language:English
Subjects:
3D bioprinting
Alginate
Bone
Cartilage
Scaffolds
Tissue engineering
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:3D printed hydrogels have emerged as a novel tissue engineering and regeneration platform due to their ability to provide a suitable environment for cell growth. To obtain a well-defined scaffold with good post-printing shape fidelity, a proper hydrogel ink formulation plays a crucial role. In this regard, alginate has received booming interest owing to its biocompatibility, biodegradability, easy functionalization, and fast gelling behavior. Hence, this review highlights the significance of alginate-based hydrogel inks for fabricating 3D printed scaffolds for bone and cartilage regeneration. Herein, we discuss the fundamentals of direct extrusion 3D bioprinting method and provide a comprehensive overview of various alginate-based hydrogel ink formulations that have been used so far. We also summarize the requirements of hydrogel inks and 3D printed scaffolds to achieve similarity to the native tissue environment. Finally, we discuss the challenges, and research directions relevant for future clinical translation. [Display omitted]
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2022.119964