Comparison of sentinel lymph node biopsy and elective neck dissection for early oral cavity squamous cell carcinoma patients with clinically node-negative necks: systematic review and meta-analysis

This study aimed to compare the prognostic utility of sentinel node biopsy and elective neck dissection in early stage clinically node-negative oral cavity squamous cell carcinoma patients. PubMed, Scopus, Embase, Web of Science and Cochrane Library databases were searched up to March 2022. Hazard r...

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Published in:Journal of laryngology and otology 2023-06, Vol.137 (6), p.599-607
Main Authors: Kang, Y J, Kang, M J, Ahn, H S, Hwang, S H
Format: Article
Language:English
Subjects:
Bias
Biopsy
Cancer
Carcinoma, Squamous Cell
Cohort analysis
Dissection
Head and Neck Neoplasms - pathology
Humans
Lymph nodes
Lymph Nodes - pathology
Lymph Nodes - surgery
Lymphatic system
Medical prognosis
Meta-analysis
Metastasis
Missing data
Mouth Neoplasms
Neck
Neck Dissection
Neoplasm Staging
Oral cancer
Oral carcinoma
Oral cavity
Otology
Ratios
Sentinel Lymph Node Biopsy
Squamous cell carcinoma
Squamous Cell Carcinoma of Head and Neck - pathology
Squamous Cell Carcinoma of Head and Neck - surgery
Systematic review
Tomography
Tumors
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description This study aimed to compare the prognostic utility of sentinel node biopsy and elective neck dissection in early stage clinically node-negative oral cavity squamous cell carcinoma patients. PubMed, Scopus, Embase, Web of Science and Cochrane Library databases were searched up to March 2022. Hazard ratios, Kaplan-Meier curves, -values and survival outcomes were extracted. Twelve studies involving 10 583 patients were included. No significant differences in overall survival between sentinel node biopsy and elective neck dissection groups were found. Heterogeneity was not detected in pooled overall survival, disease-free survival and disease-specific survival analyses (all I less than 50). In subgroup analyses by follow-up period, sentinel node biopsy and elective neck dissection had similar prognostic value. Sentinel node biopsy might be a valuable alternative to elective neck dissection for the management of early stage clinically node-negative oral cavity squamous cell carcinoma.
doi_str_mv 10.1017/S0022215122002043
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Laryngol. Otol</addtitle><date>2023-06-01</date><risdate>2023</risdate><volume>137</volume><issue>6</issue><spage>599</spage><epage>607</epage><pages>599-607</pages><issn>0022-2151</issn><eissn>1748-5460</eissn><abstract>This study aimed to compare the prognostic utility of sentinel node biopsy and elective neck dissection in early stage clinically node-negative oral cavity squamous cell carcinoma patients. PubMed, Scopus, Embase, Web of Science and Cochrane Library databases were searched up to March 2022. Hazard ratios, Kaplan-Meier curves, -values and survival outcomes were extracted. Twelve studies involving 10 583 patients were included. No significant differences in overall survival between sentinel node biopsy and elective neck dissection groups were found. Heterogeneity was not detected in pooled overall survival, disease-free survival and disease-specific survival analyses (all I less than 50). 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subjects Bias
Biopsy
Cancer
Carcinoma, Squamous Cell
Cohort analysis
Dissection
Head and Neck Neoplasms - pathology
Humans
Lymph nodes
Lymph Nodes - pathology
Lymph Nodes - surgery
Lymphatic system
Medical prognosis
Meta-analysis
Metastasis
Missing data
Mouth Neoplasms
Neck
Neck Dissection
Neoplasm Staging
Oral cancer
Oral carcinoma
Oral cavity
Otology
Ratios
Sentinel Lymph Node Biopsy
Squamous cell carcinoma
Squamous Cell Carcinoma of Head and Neck - pathology
Squamous Cell Carcinoma of Head and Neck - surgery
Systematic review
Tomography
Tumors
title Comparison of sentinel lymph node biopsy and elective neck dissection for early oral cavity squamous cell carcinoma patients with clinically node-negative necks: systematic review and meta-analysis
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