Importance of anti-centromere antibodies in the diagnosis of Sjögren’s syndrome

The purpose of the present study was to indicate that patients with anti-centromere antibodies (ACA) also experience ocular/oral dryness like patients with anti-Ro/SSA and/or anti-La/SSB antibodies (anti-SSA/SSB). A total of 80 patients with subjective ocular and/or oral dryness were classified into...

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Bibliographic Details
Published in:Journal of Oral Science 2022, Vol.64(4), pp.324-326
Main Authors: Kitagawa, Masae, Sugimoto, Tomohiro, Ogawa, Ikuko, Miyauchi, Mutsumi, Hirata, Shintaro, Sugiyama, Eiji
Format: Article
Language:English
Subjects:
anti-centromere antibody
anti-Ro/SSA and anti-La/SSB antibodies
collagen fiber
dryness
Sjögren’s syndrome
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Summary:The purpose of the present study was to indicate that patients with anti-centromere antibodies (ACA) also experience ocular/oral dryness like patients with anti-Ro/SSA and/or anti-La/SSB antibodies (anti-SSA/SSB). A total of 80 patients with subjective ocular and/or oral dryness were classified into two groups, namely, anti-SSA/SSB-positive (anti-SSA/SSB [+]) group and ACA-positive (ACA [+]) group. The degree of ocular and oral dryness in ACA (+) patients is similar to that in anti-SSA/SSB (+) patients. On histopathological examination of the labial glands, the area of fibrosis was significantly larger in the ACA (+) group than in the anti-SSA/SSB (+) group. Thus, ACA (+) patients should be examined for Sjögren’s syndrome.
ISSN:1343-4934
1880-4926
DOI:10.2334/josnusd.22-0231