CD47 expression and tumor-associated immune cells in breast cancer and their correlation with molecular subtypes and prognostic factors

• Published in: Pathology, research and practice research and practice, 2022-10, Vol.238, p.154107-154107, Article 154107
• Main Authors: Celepli, Pınar, Karabulut, Sefika, Bigat, İrem, Celepli, Salih, Hücümenoğlu, Sema
• Format: Article
• Language: English
• Subjects: Breast cancer; CD163; CD3; CD47; Tumor associated immune cells
• ISSN: 0344-0338; 1618-0631
• DOI: 10.1016/j.prp.2022.154107

Breast cancer is the most common malignancy in women and a heterogeneous disease at the molecular level. Since most breast cancer cases are not of a special type, it is suggested that tumor-associated macrophages and tumor-infiltrating lymphocytes, which are involved in tumor growth, invasion, angiogenesis, and metastasis, may be important factors that should be evaluated together with standard criteria to determine the prognosis of cancer and assist in treatment decisions and outcome stratification. In this study, CD47 expression, which is involved in macrophage-mediated immune escape, tumor-infiltrating lymphocytes, and tumor-associated macrophages were evaluated in breast cancer molecular subgroups and correlated with prognostic factors. The immunohistochemistry of CD47, CD163, and CD3 was analyzed on the tissue microarrays of 278 invasive breast cancer cases. The CD47, CD163, and CD3 expressions were found to be correlated with various clinicopathological parameters in breast cancer. High levels of CD47, CD163, and CD3 expressions had a significant correlation with the ER status and PR status, Ki-67 proliferation index, and molecular subtype (P