Can trajectory nor‐epinephrine infiltration reduce blood loss during percutaneous nephrolithotomy? A double‐blinded randomized controlled trial

Purpose To determine the efficacy and safety of trajectory infiltration with 1:150 000 Norepinephrine (NE) in reducing blood loss during percutaneous nephrolithotomy (PCNL). Materials and methods This is a prospective randomized double‐blinded placebo‐controlled trial. In all, 140 consecutive patien...

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Bibliographic Details
Published in:International journal of urology 2022-12, Vol.29 (12), p.1535-1542
Main Authors: El‐Shaer, Waleed, Haggag, Mohamed Salah, Elshaer, Alaa, Shaboob, Islam, Kandeel, Wael, Elmohamady, Basheer, Abdelmotaleb, Dina Saad, Abdel‐Lateef, Sally
Format: Article
Language:English
Subjects:
Blood
blood loss
Calcification (ectopic)
Epinephrine
Hematocrit
Hemoglobin
Humans
Infiltration
Kidney Calculi - surgery
Nephrolithiasis
Nephrolithotomy, Percutaneous - adverse effects
Nephrostomy, Percutaneous - adverse effects
Norepinephrine
PCNL
Placebos
Prospective Studies
renal stones
stone free rate
Treatment Outcome
Urological surgery
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Summary:Purpose To determine the efficacy and safety of trajectory infiltration with 1:150 000 Norepinephrine (NE) in reducing blood loss during percutaneous nephrolithotomy (PCNL). Materials and methods This is a prospective randomized double‐blinded placebo‐controlled trial. In all, 140 consecutive patients underwent PCNL for the management of large renal calculi. They were randomly assigned (1:1) to one of either study groups, the NE‐PCNL group (70 patients whose PCNL‐trajectory was infiltrated by NE) or the Placebo group (saline PCNL) (70 patients whose PCNL tracts were infiltrated by normal saline). Procedure‐related blood loss (the primary outcome) was assessed and statistically analyzed. Also, all other procedure‐related events and complications were recorded and compared. Results The median blood loss was 378 ml (IQR: 252–504) in the NE‐PCNL group versus 592 ml (IQR: 378–756) in the S‐PCNL group (p 
ISSN:0919-8172
1442-2042
DOI:10.1111/iju.15036