Palladium-Catalyzed Direct Decarbonylative Cyanation of Aryl Carboxylic Acids

The direct transformation of aryl carboxylic acids to aryl nitrile compounds is an interesting topic because carboxylic acids are not only abundant in nature but are also inexpensive and stable. Here, the synthesis of a series of aryl nitriles by palladium-catalyzed decarbonylative cyanation of carb...

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Bibliographic Details
Published in:Journal of organic chemistry 2022-10, Vol.87 (19), p.12791-12798
Main Authors: Zhang, Guofu, Miao, Huihui, Guan, Chenfei, Ding, Chengrong
Format: Article
Language:English
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Summary:The direct transformation of aryl carboxylic acids to aryl nitrile compounds is an interesting topic because carboxylic acids are not only abundant in nature but are also inexpensive and stable. Here, the synthesis of a series of aryl nitriles by palladium-catalyzed decarbonylative cyanation of carboxylic acids without base has been achieved. The successful decarbonylative cyanation of drug molecules and Gram-scale reaction to verify the practicality and operability of this method are analyzed.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.2c01401