The role and function of CLU in cancer biology and therapy

Clusterin (CLU) is a highly evolutionary conserved glycoprotein with multiple isoform-specific functions and is widely distributed in different species. Accumulated evidence has shown the prominent role of CLU in regulating several essential physiological processes, including programmed cell death,...

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Bibliographic Details
Published in:Clinical and experimental medicine 2023-09, Vol.23 (5), p.1375-1391
Main Authors: Zhang, Yefei, Lv, Xiang, Chen, Liming, Liu, Yan
Format: Article
Language:English
Subjects:
Apoptosis
Cancer therapies
Cell death
Clusterin
Colon cancer
Evolutionary conservation
Hematology
Internal Medicine
Medicine
Medicine & Public Health
Metastases
Oncology
Pancreatic cancer
Review Article
Therapeutic targets
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Summary:Clusterin (CLU) is a highly evolutionary conserved glycoprotein with multiple isoform-specific functions and is widely distributed in different species. Accumulated evidence has shown the prominent role of CLU in regulating several essential physiological processes, including programmed cell death, metastasis, invasion, proliferation and cell growth via regulating diverse signaling pathways to mediate cancer progression in various cancers, such as prostate, breast, lung, liver, colon, bladder and pancreatic cancer. Several studies have revealed the potential benefit of inhibiting CLU in CLU inhibition-based targeted cancer therapies in vitro, in vivo or in human, suggesting CLU is a promising therapeutic target. This review discusses the multiple functions and mechanisms of CLU in regulating tumor progression of various cancers and summarizes the inhibitors of CLU used in CLU inhibition-based targeted cancer therapies.
ISSN:1591-9528
1591-8890
1591-9528
DOI:10.1007/s10238-022-00885-2