Vascular and neuronal effects of general anesthesia on the brain: An fMRI study

Background and Purpose A number of functional magnetic resonance imaging (fMRI) studies rely on application of anesthetic agents during scanning that can modulate and complicate interpretation of the measured hemodynamic blood oxygenation level‐dependent (BOLD) response. The purpose of the present s...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neuroimaging 2023-01, Vol.33 (1), p.109-120
Main Authors: Vedaei, Faezeh, Alizadeh, Mahdi, Tantawi, Mohamed, Romo, Victor, Mohamed, Feroze B., Wu, Chengyuan
Format: Article
Language:English
Subjects:
Anesthesia
Anesthesia, General
Anesthetics
BOLD response
Brain
Brain - blood supply
Brain mapping
breath‐holding fMRI
Cerebrovascular Circulation - physiology
cerebrovascular reactivity
Epilepsy
Functional magnetic resonance imaging
General anesthesia
Hemodynamics
Humans
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Medical imaging
Neuroimaging
neuronal activity
Oxygen
Oxygenation
Sleep and wakefulness
Wakefulness
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background and Purpose A number of functional magnetic resonance imaging (fMRI) studies rely on application of anesthetic agents during scanning that can modulate and complicate interpretation of the measured hemodynamic blood oxygenation level‐dependent (BOLD) response. The purpose of the present study was to investigate the effect of general anesthesia on two main components of BOLD signal including neuronal activity and vascular response. Methods Breath‐holding (BH) fMRI was conducted in wakefulness and under anesthesia states in 9 patients with drug‐resistant epilepsy who needed to get scanned under anesthesia during laser interstitial thermal therapy. BOLD and BOLD cerebrovascular reactivity (BOLD‐CVR) maps were compared using t‐test between two states to assess the effect of anesthesia on neuronal activity and vascular factors (p 
ISSN:1051-2284
1552-6569
DOI:10.1111/jon.13049