Synthesis of Enamines, Aldehydes, and Nitriles from CO2: Scope of the One-Pot Strategy via Formamides

Tetrabutylammonium acetate (TBAA) and Cu­(OAc)2 worked as a binary catalytic system for the solvent-free N-formylation of amines with CO2 and PhSiH3. This catalysis making C–H and C–N bonds with CO2 was coupled with the C–C bond-forming reactions to achieve the one-pot synthesis of enamines, aldehyd...

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Bibliographic Details
Published in:Journal of organic chemistry 2023-11, Vol.88 (21), p.15444-15451
Main Authors: Nakaoka, Koichi, Guo, Chao, Saiki, Yuta, Furukawa, Shin, Ema, Tadashi
Format: Article
Language:English
Online Access:Get full text
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Summary:Tetrabutylammonium acetate (TBAA) and Cu­(OAc)2 worked as a binary catalytic system for the solvent-free N-formylation of amines with CO2 and PhSiH3. This catalysis making C–H and C–N bonds with CO2 was coupled with the C–C bond-forming reactions to achieve the one-pot synthesis of enamines, aldehydes, and nitriles. The X-ray crystal structure of a Cu­(OAc)2–TBAA complex was also revealed.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.2c01666