Pancreatic fibrosis by extracellular volume fraction using Contrast-enhanced computed tomography and relationship with pancreatic cancer

•1. Histologic pancreatic fibrosis fraction was found to be significantly correlated with ECV.•2. ECV was significantly higher in the pancreatic cancer group than in the control group.•3. Pancreatic cancer can be predicted by early detecting fibrosis of the pancreas using ECV. This study aimed to as...

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Published in:European journal of radiology 2022-11, Vol.156, p.110522, Article 110522
Main Authors: Fukui, Hideyuki, Onishi, Hiromitsu, Nakamoto, Atsushi, Tsuboyama, Takahiro, Ota, Takashi, Yano, Keigo, Enchi, Yukihiro, Yamada, Daisaku, Takeda, Yu, Kobayashi, Shogo, Fukuda, Yasunari, Eguchi, Hidetoshi, Matsui, Takahiro, Tatsumi, Mitsuaki, Tomiyama, Noriyuki
Format: Article
Language:English
Subjects:
Contrast Media
Diagnostic Imaging
Fibrosis
Multidetector Computed Tomography
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Summary:•1. Histologic pancreatic fibrosis fraction was found to be significantly correlated with ECV.•2. ECV was significantly higher in the pancreatic cancer group than in the control group.•3. Pancreatic cancer can be predicted by early detecting fibrosis of the pancreas using ECV. This study aimed to assess the relationship between pancreatic fibrosis measured by the extracellular volume fraction (ECV) using contrast-enhanced computed tomography (CT) and the histologic pancreatic fibrosis fraction and investigate the relationship between pancreatic fibrosis and pancreatic cancer. The study included 88 consecutive patients (48 males, 40 females; median age, 69 years; range, 17–89 years); 47 had pancreatic cancer, and 41 had other diseases. Fifty-two cases were evaluated pathologically for pancreatic fibrosis. The histologic pancreatic fibrosis fraction was quantified using image analysis software in nontumorous pancreatic tissue at the resection stump using 2-µm-thick Azan-stained slides. Two board-certified radiologists measured ECV in the pancreatic parenchyma at an estimated transection line. The correlation between histologic pancreatic fibrosis fraction and ECV was investigated, and whether the ECV value could be used as a biomarker for pancreatic cancer was investigated. The histologic pancreatic fibrosis fraction was significantly correlated with the ECV (r = 0.64, P 
ISSN:0720-048X
1872-7727
1872-7727
DOI:10.1016/j.ejrad.2022.110522