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Clonazepam for the management of sleep disorders
Background The objectives of this review and meta-analysis of polysomnographic data are those to focus on the clinical use of clonazepam for the management of sleep disorders by re-analyzing clinical trials and randomized clinical trials which have been published in peer-reviewed journals. Methods A...
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Published in: | Neurological sciences 2023, Vol.44 (1), p.115-128 |
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description | Background
The objectives of this review and meta-analysis of polysomnographic data are those to focus on the clinical use of clonazepam for the management of sleep disorders by re-analyzing clinical trials and randomized clinical trials which have been published in peer-reviewed journals.
Methods
A review of the literature including clinical trials and randomized controlled trials was performed in PubMed®, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement protocol. A random effects model meta-analysis was then carried out for the four more frequently reported polysomnographic measures: total sleep time, sleep latency, sleep efficiency, and periodic leg movement during sleep (PLMS) index.
Results
A total of 33 articles were retrieved and screened in full text, of which 18 met the criteria for review; among the latter, nine met the criteria for meta-analysis. The studies included in the review involved patients with insomnia, REM sleep behavior disorder, sleep bruxism, and restless leg syndrome or PLMS which reported, most often, an increase in total sleep time with clonazepam. A clear sleep-promoting effect of clonazepam was found also by meta-analysis.
Discussion and conclusions
Our results indicate that the pharmacological treatment of sleep disorders with clonazepam must always be personalized according to the type of patient, the risk of addiction and the concomitant presence of respiratory disorders are key factors to take into account. However, in light of the clinical evidence of the few studies in the literature on the different types of disorders, more studies on the use of clonazepam (also in association with first choice treatments) are definitely needed. |
doi_str_mv | 10.1007/s10072-022-06397-x |
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The objectives of this review and meta-analysis of polysomnographic data are those to focus on the clinical use of clonazepam for the management of sleep disorders by re-analyzing clinical trials and randomized clinical trials which have been published in peer-reviewed journals.
Methods
A review of the literature including clinical trials and randomized controlled trials was performed in PubMed®, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement protocol. A random effects model meta-analysis was then carried out for the four more frequently reported polysomnographic measures: total sleep time, sleep latency, sleep efficiency, and periodic leg movement during sleep (PLMS) index.
Results
A total of 33 articles were retrieved and screened in full text, of which 18 met the criteria for review; among the latter, nine met the criteria for meta-analysis. The studies included in the review involved patients with insomnia, REM sleep behavior disorder, sleep bruxism, and restless leg syndrome or PLMS which reported, most often, an increase in total sleep time with clonazepam. A clear sleep-promoting effect of clonazepam was found also by meta-analysis.
Discussion and conclusions
Our results indicate that the pharmacological treatment of sleep disorders with clonazepam must always be personalized according to the type of patient, the risk of addiction and the concomitant presence of respiratory disorders are key factors to take into account. However, in light of the clinical evidence of the few studies in the literature on the different types of disorders, more studies on the use of clonazepam (also in association with first choice treatments) are definitely needed.</description><identifier>ISSN: 1590-1874</identifier><identifier>EISSN: 1590-3478</identifier><identifier>DOI: 10.1007/s10072-022-06397-x</identifier><identifier>PMID: 36112279</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Addictions ; Benzodiazepines ; Clinical trials ; Clonazepam ; Clonazepam - pharmacology ; Clonazepam - therapeutic use ; Drug therapy ; Humans ; Latency ; Leg ; Literature reviews ; Medicine ; Medicine & Public Health ; Meta-analysis ; Neurology ; Neuroradiology ; Neurosciences ; Neurosurgery ; Patients ; Polysomnography - methods ; Psychiatry ; REM sleep ; Restless Legs Syndrome - complications ; Review Article ; Sleep ; Sleep disorders</subject><ispartof>Neurological sciences, 2023, Vol.44 (1), p.115-128</ispartof><rights>Fondazione Società Italiana di Neurologia 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2022. Fondazione Società Italiana di Neurologia.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c305t-d1a960a88b79309357f7b04422a602d0ac10a4488a0408a9f0411944e2702ae23</citedby><cites>FETCH-LOGICAL-c305t-d1a960a88b79309357f7b04422a602d0ac10a4488a0408a9f0411944e2702ae23</cites><orcidid>0000-0001-9414-1995</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36112279$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Raggi, Alberto</creatorcontrib><creatorcontrib>Mogavero, Maria Paola</creatorcontrib><creatorcontrib>DelRosso, Lourdes M.</creatorcontrib><creatorcontrib>Ferri, Raffaele</creatorcontrib><title>Clonazepam for the management of sleep disorders</title><title>Neurological sciences</title><addtitle>Neurol Sci</addtitle><addtitle>Neurol Sci</addtitle><description>Background
The objectives of this review and meta-analysis of polysomnographic data are those to focus on the clinical use of clonazepam for the management of sleep disorders by re-analyzing clinical trials and randomized clinical trials which have been published in peer-reviewed journals.
Methods
A review of the literature including clinical trials and randomized controlled trials was performed in PubMed®, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement protocol. A random effects model meta-analysis was then carried out for the four more frequently reported polysomnographic measures: total sleep time, sleep latency, sleep efficiency, and periodic leg movement during sleep (PLMS) index.
Results
A total of 33 articles were retrieved and screened in full text, of which 18 met the criteria for review; among the latter, nine met the criteria for meta-analysis. The studies included in the review involved patients with insomnia, REM sleep behavior disorder, sleep bruxism, and restless leg syndrome or PLMS which reported, most often, an increase in total sleep time with clonazepam. A clear sleep-promoting effect of clonazepam was found also by meta-analysis.
Discussion and conclusions
Our results indicate that the pharmacological treatment of sleep disorders with clonazepam must always be personalized according to the type of patient, the risk of addiction and the concomitant presence of respiratory disorders are key factors to take into account. However, in light of the clinical evidence of the few studies in the literature on the different types of disorders, more studies on the use of clonazepam (also in association with first choice treatments) are definitely needed.</description><subject>Addictions</subject><subject>Benzodiazepines</subject><subject>Clinical trials</subject><subject>Clonazepam</subject><subject>Clonazepam - pharmacology</subject><subject>Clonazepam - therapeutic use</subject><subject>Drug therapy</subject><subject>Humans</subject><subject>Latency</subject><subject>Leg</subject><subject>Literature reviews</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meta-analysis</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Neurosurgery</subject><subject>Patients</subject><subject>Polysomnography - methods</subject><subject>Psychiatry</subject><subject>REM sleep</subject><subject>Restless Legs Syndrome - complications</subject><subject>Review Article</subject><subject>Sleep</subject><subject>Sleep disorders</subject><issn>1590-1874</issn><issn>1590-3478</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LxDAQhoMo7rr6BzxIwYuX6uSjTXKUxS8QvOg5ZNvpukvb1KSF1V9v1q4KHjxkEphn3gkPIacULimAvArbylJg8eRcy3SzR6Y005ByIdX-7k2VFBNyFMIaAKig_JBMeE4pY1JPCcxr19oP7GyTVM4n_SsmjW3tEhts-8RVSagRu6RcBedL9OGYHFS2Dniyu2fk5fbmeX6fPj7dPcyvH9OCQ9anJbU6B6vUQmoOmmeykgsQgjGbAyvBFhSsEEpZEKCsrkBQqoVAJoFZZHxGLsbczru3AUNvmlUosK5ti24IhkmaxTiV64ie_0HXbvBt_F2kctCa8SyPFBupwrsQPFam86vG-ndDwWxNmtGniT7Nl0-ziUNnu-hh0WD5M_ItMAJ8BEJstUv0v7v_if0EKXJ9kw</recordid><startdate>2023</startdate><enddate>2023</enddate><creator>Raggi, Alberto</creator><creator>Mogavero, Maria Paola</creator><creator>DelRosso, Lourdes M.</creator><creator>Ferri, Raffaele</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9414-1995</orcidid></search><sort><creationdate>2023</creationdate><title>Clonazepam for the management of sleep disorders</title><author>Raggi, Alberto ; Mogavero, Maria Paola ; DelRosso, Lourdes M. ; Ferri, Raffaele</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c305t-d1a960a88b79309357f7b04422a602d0ac10a4488a0408a9f0411944e2702ae23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Addictions</topic><topic>Benzodiazepines</topic><topic>Clinical trials</topic><topic>Clonazepam</topic><topic>Clonazepam - pharmacology</topic><topic>Clonazepam - therapeutic use</topic><topic>Drug therapy</topic><topic>Humans</topic><topic>Latency</topic><topic>Leg</topic><topic>Literature reviews</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meta-analysis</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Neurosurgery</topic><topic>Patients</topic><topic>Polysomnography - methods</topic><topic>Psychiatry</topic><topic>REM sleep</topic><topic>Restless Legs Syndrome - complications</topic><topic>Review Article</topic><topic>Sleep</topic><topic>Sleep disorders</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Raggi, Alberto</creatorcontrib><creatorcontrib>Mogavero, Maria Paola</creatorcontrib><creatorcontrib>DelRosso, Lourdes M.</creatorcontrib><creatorcontrib>Ferri, Raffaele</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Proquest Health & Medical Complete</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Psychology Database (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Raggi, Alberto</au><au>Mogavero, Maria Paola</au><au>DelRosso, Lourdes M.</au><au>Ferri, Raffaele</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clonazepam for the management of sleep disorders</atitle><jtitle>Neurological sciences</jtitle><stitle>Neurol Sci</stitle><addtitle>Neurol Sci</addtitle><date>2023</date><risdate>2023</risdate><volume>44</volume><issue>1</issue><spage>115</spage><epage>128</epage><pages>115-128</pages><issn>1590-1874</issn><eissn>1590-3478</eissn><abstract>Background
The objectives of this review and meta-analysis of polysomnographic data are those to focus on the clinical use of clonazepam for the management of sleep disorders by re-analyzing clinical trials and randomized clinical trials which have been published in peer-reviewed journals.
Methods
A review of the literature including clinical trials and randomized controlled trials was performed in PubMed®, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement protocol. A random effects model meta-analysis was then carried out for the four more frequently reported polysomnographic measures: total sleep time, sleep latency, sleep efficiency, and periodic leg movement during sleep (PLMS) index.
Results
A total of 33 articles were retrieved and screened in full text, of which 18 met the criteria for review; among the latter, nine met the criteria for meta-analysis. The studies included in the review involved patients with insomnia, REM sleep behavior disorder, sleep bruxism, and restless leg syndrome or PLMS which reported, most often, an increase in total sleep time with clonazepam. A clear sleep-promoting effect of clonazepam was found also by meta-analysis.
Discussion and conclusions
Our results indicate that the pharmacological treatment of sleep disorders with clonazepam must always be personalized according to the type of patient, the risk of addiction and the concomitant presence of respiratory disorders are key factors to take into account. However, in light of the clinical evidence of the few studies in the literature on the different types of disorders, more studies on the use of clonazepam (also in association with first choice treatments) are definitely needed.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>36112279</pmid><doi>10.1007/s10072-022-06397-x</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0001-9414-1995</orcidid></addata></record> |
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subjects | Addictions Benzodiazepines Clinical trials Clonazepam Clonazepam - pharmacology Clonazepam - therapeutic use Drug therapy Humans Latency Leg Literature reviews Medicine Medicine & Public Health Meta-analysis Neurology Neuroradiology Neurosciences Neurosurgery Patients Polysomnography - methods Psychiatry REM sleep Restless Legs Syndrome - complications Review Article Sleep Sleep disorders |
title | Clonazepam for the management of sleep disorders |
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