Amphotericin B May Decrease the Serum Level of Voriconazole: A Case Report and Brief Review of Literature

BackgroundCombination therapy with amphotericin B (AmB) and Voriconazole are sometimes used due to reducing AmB-related adverse reactions and improving outcomes. However, there was no report whether AmB would affect the serum level of Voriconazole. Case PresentationA patient was in presumption of in...

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Bibliographic Details
Published in:Infection and drug resistance 2022, Vol.15, p.5397-5400
Main Authors: Hu, Zhen, Zhou, Huaying
Format: Report
Language:English
Online Access:Get full text
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Summary:BackgroundCombination therapy with amphotericin B (AmB) and Voriconazole are sometimes used due to reducing AmB-related adverse reactions and improving outcomes. However, there was no report whether AmB would affect the serum level of Voriconazole. Case PresentationA patient was in presumption of invasive fungal infection. Voriconazole and amphotericin B was combined for administration. The results showed that serum levels of Voriconazole were dramatically reduced when combined AmB, whereas went up when receiving Voriconazole alone. ConclusionAmB might decrease the level of Voriconazole. Such a combination of AmB and Voriconazole cannot be considered appropriate until more data are available.
ISSN:1178-6973
1178-6973
DOI:10.2147/IDR.S374853