Amphotericin B May Decrease the Serum Level of Voriconazole: A Case Report and Brief Review of Literature

BackgroundCombination therapy with amphotericin B (AmB) and Voriconazole are sometimes used due to reducing AmB-related adverse reactions and improving outcomes. However, there was no report whether AmB would affect the serum level of Voriconazole. Case PresentationA patient was in presumption of in...

Full description

Saved in:
Bibliographic Details
Published in:Infection and drug resistance 2022, Vol.15, p.5397-5400
Main Authors: Hu, Zhen, Zhou, Huaying
Format: Report
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 5400
container_issue
container_start_page 5397
container_title Infection and drug resistance
container_volume 15
creator Hu, Zhen
Zhou, Huaying
description BackgroundCombination therapy with amphotericin B (AmB) and Voriconazole are sometimes used due to reducing AmB-related adverse reactions and improving outcomes. However, there was no report whether AmB would affect the serum level of Voriconazole. Case PresentationA patient was in presumption of invasive fungal infection. Voriconazole and amphotericin B was combined for administration. The results showed that serum levels of Voriconazole were dramatically reduced when combined AmB, whereas went up when receiving Voriconazole alone. ConclusionAmB might decrease the level of Voriconazole. Such a combination of AmB and Voriconazole cannot be considered appropriate until more data are available.
doi_str_mv 10.2147/IDR.S374853
format report
fullrecord <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_miscellaneous_2715789093</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2715789093</sourcerecordid><originalsourceid>FETCH-proquest_miscellaneous_27157890933</originalsourceid><addsrcrecordid>eNqVzL1uwjAUBWCraqWiwtQXuGMXaBwHnLDxKyrBAlVXZKUnwpUTB9sBwdM3SAxde5dzdPTpMvbKo0HME_n-Md8OdkIm6VA8sA7nMu2PMike__Rn1vP-J2pPZKNExh2mJ2V9sAFO57qiKW3UhebIHZQHhQNoB9eUtMYJhmxBX7aVtlJXazCmCc1ubovaukCq-qap0yja4aRxvvm1bn-r0Dh02VOhjEfvni_sbbn4nK36tbPHBj7sS-1zGKMq2MbvY8mHMs2iTIh_0F_wAFEQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>report</recordtype><pqid>2715789093</pqid></control><display><type>report</type><title>Amphotericin B May Decrease the Serum Level of Voriconazole: A Case Report and Brief Review of Literature</title><source>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</source><source>Taylor &amp; Francis Open Access</source><source>PubMed Central</source><creator>Hu, Zhen ; Zhou, Huaying</creator><creatorcontrib>Hu, Zhen ; Zhou, Huaying</creatorcontrib><description>BackgroundCombination therapy with amphotericin B (AmB) and Voriconazole are sometimes used due to reducing AmB-related adverse reactions and improving outcomes. However, there was no report whether AmB would affect the serum level of Voriconazole. Case PresentationA patient was in presumption of invasive fungal infection. Voriconazole and amphotericin B was combined for administration. The results showed that serum levels of Voriconazole were dramatically reduced when combined AmB, whereas went up when receiving Voriconazole alone. ConclusionAmB might decrease the level of Voriconazole. Such a combination of AmB and Voriconazole cannot be considered appropriate until more data are available.</description><identifier>ISSN: 1178-6973</identifier><identifier>EISSN: 1178-6973</identifier><identifier>DOI: 10.2147/IDR.S374853</identifier><language>eng</language><ispartof>Infection and drug resistance, 2022, Vol.15, p.5397-5400</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>780,784,4488,27923,37011</link.rule.ids></links><search><creatorcontrib>Hu, Zhen</creatorcontrib><creatorcontrib>Zhou, Huaying</creatorcontrib><title>Amphotericin B May Decrease the Serum Level of Voriconazole: A Case Report and Brief Review of Literature</title><title>Infection and drug resistance</title><description>BackgroundCombination therapy with amphotericin B (AmB) and Voriconazole are sometimes used due to reducing AmB-related adverse reactions and improving outcomes. However, there was no report whether AmB would affect the serum level of Voriconazole. Case PresentationA patient was in presumption of invasive fungal infection. Voriconazole and amphotericin B was combined for administration. The results showed that serum levels of Voriconazole were dramatically reduced when combined AmB, whereas went up when receiving Voriconazole alone. ConclusionAmB might decrease the level of Voriconazole. Such a combination of AmB and Voriconazole cannot be considered appropriate until more data are available.</description><issn>1178-6973</issn><issn>1178-6973</issn><fulltext>true</fulltext><rsrctype>report</rsrctype><creationdate>2022</creationdate><recordtype>report</recordtype><recordid>eNqVzL1uwjAUBWCraqWiwtQXuGMXaBwHnLDxKyrBAlVXZKUnwpUTB9sBwdM3SAxde5dzdPTpMvbKo0HME_n-Md8OdkIm6VA8sA7nMu2PMike__Rn1vP-J2pPZKNExh2mJ2V9sAFO57qiKW3UhebIHZQHhQNoB9eUtMYJhmxBX7aVtlJXazCmCc1ubovaukCq-qap0yja4aRxvvm1bn-r0Dh02VOhjEfvni_sbbn4nK36tbPHBj7sS-1zGKMq2MbvY8mHMs2iTIh_0F_wAFEQ</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Hu, Zhen</creator><creator>Zhou, Huaying</creator><scope>7X8</scope></search><sort><creationdate>20220101</creationdate><title>Amphotericin B May Decrease the Serum Level of Voriconazole: A Case Report and Brief Review of Literature</title><author>Hu, Zhen ; Zhou, Huaying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_27157890933</frbrgroupid><rsrctype>reports</rsrctype><prefilter>reports</prefilter><language>eng</language><creationdate>2022</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Hu, Zhen</creatorcontrib><creatorcontrib>Zhou, Huaying</creatorcontrib><collection>MEDLINE - Academic</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hu, Zhen</au><au>Zhou, Huaying</au><format>book</format><genre>unknown</genre><ristype>RPRT</ristype><atitle>Amphotericin B May Decrease the Serum Level of Voriconazole: A Case Report and Brief Review of Literature</atitle><jtitle>Infection and drug resistance</jtitle><date>2022-01-01</date><risdate>2022</risdate><volume>15</volume><spage>5397</spage><epage>5400</epage><pages>5397-5400</pages><issn>1178-6973</issn><eissn>1178-6973</eissn><abstract>BackgroundCombination therapy with amphotericin B (AmB) and Voriconazole are sometimes used due to reducing AmB-related adverse reactions and improving outcomes. However, there was no report whether AmB would affect the serum level of Voriconazole. Case PresentationA patient was in presumption of invasive fungal infection. Voriconazole and amphotericin B was combined for administration. The results showed that serum levels of Voriconazole were dramatically reduced when combined AmB, whereas went up when receiving Voriconazole alone. ConclusionAmB might decrease the level of Voriconazole. Such a combination of AmB and Voriconazole cannot be considered appropriate until more data are available.</abstract><doi>10.2147/IDR.S374853</doi></addata></record>
fulltext fulltext
identifier ISSN: 1178-6973
ispartof Infection and drug resistance, 2022, Vol.15, p.5397-5400
issn 1178-6973
1178-6973
language eng
recordid cdi_proquest_miscellaneous_2715789093
source Publicly Available Content Database (Proquest) (PQ_SDU_P3); Taylor & Francis Open Access; PubMed Central
title Amphotericin B May Decrease the Serum Level of Voriconazole: A Case Report and Brief Review of Literature
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T12%3A32%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=unknown&rft.atitle=Amphotericin%20B%20May%20Decrease%20the%20Serum%20Level%20of%20Voriconazole:%20A%20Case%20Report%20and%20Brief%20Review%20of%20Literature&rft.jtitle=Infection%20and%20drug%20resistance&rft.au=Hu,%20Zhen&rft.date=2022-01-01&rft.volume=15&rft.spage=5397&rft.epage=5400&rft.pages=5397-5400&rft.issn=1178-6973&rft.eissn=1178-6973&rft_id=info:doi/10.2147/IDR.S374853&rft_dat=%3Cproquest%3E2715789093%3C/proquest%3E%3Cgrp_id%3Ecdi_FETCH-proquest_miscellaneous_27157890933%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2715789093&rft_id=info:pmid/&rfr_iscdi=true