A natural history study of coagulopathy in a porcine 40% total body surface area burn model reveals the time-dependent significance of functional assays

Various studies have reported discordant results on the magnitude and direction of burn-induced coagulopathy (BIC), which has recently been associated with multiple organ dysfunction syndrome (MODS) and death. The increased mechanistic understanding of BIC is due, in part, to novel assays that have...

Full description

Saved in:
Bibliographic Details
Published in:Burns 2022-12, Vol.48 (8), p.1805-1815
Main Authors: McDonough, Matthew M., Keyloun, John, Orfeo, Thomas, Brummel-Zeidins, Kathleen, Bynum, James A., Wu, Xiaowu, Darlington, Daniel N., Shupp, Jeffrey W., Burmeister, David M.
Format: Article
Language:English
Subjects:
Aggregometry
Animals
Blood Coagulation Disorders - etiology
Body Surface Area
Burns
Burns - complications
Coagulopathy
Swine
Thrombelastography - methods
Thrombin
Thrombin generation
Thromboelastography
Thromboelastometry
Thrombophilia
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Various studies have reported discordant results on the magnitude and direction of burn-induced coagulopathy (BIC), which has recently been associated with multiple organ dysfunction syndrome (MODS) and death. The increased mechanistic understanding of BIC is due, in part, to novel assays that have expanded the armamentarium beyond traditional tests like PT and aPTT. Still, BIC is a dynamic process, and the progression is difficult to define in the thermally-injured. To this end, we aimed to enhance the understanding of burn-induced coagulation abnormalities by employing functional assessments of platelet aggregation, viscoelastic kinetics, and thrombin generation in an extensive burn model in swine. Anesthetized Yorkshire pigs sustained 40% total body surface area (TBSA) full-thickness contact burns and recovered in metabolic cages. Blood was collected at baseline (BL), as well as 6, 24, and 48 h after injury. A significant effect of burn (P 
ISSN:0305-4179
1879-1409
DOI:10.1016/j.burns.2022.08.016