Immunolabelling of c-KIT and CAM5.2 in Canine Anal Sac Gland Adenocarcinoma

The role of c-KIT receptor in anal sac gland adenocarcinoma (ASGAC) is unclear despite its importance in the development of tumours. In this preliminary study, the expression of c-KIT was investigated in rarely observed canine ASGAC. The potential use of CAM5.2 in distinguishing ASGAC from perianal...

Full description

Saved in:
Bibliographic Details
Published in:Journal of comparative pathology 2022-10, Vol.198, p.56-61
Main Authors: İpek, Emrah, Epikmen, Erkmen T., Tunca, Recai
Format: Article
Language:English
Subjects:
anal sac gland adenocarcinoma
c-KIT
CAM5.2
canine
perianal gland tumours
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The role of c-KIT receptor in anal sac gland adenocarcinoma (ASGAC) is unclear despite its importance in the development of tumours. In this preliminary study, the expression of c-KIT was investigated in rarely observed canine ASGAC. The potential use of CAM5.2 in distinguishing ASGAC from perianal gland tumours was also evaluated. ASGAC was diagnosed in five out of 25 examined perianal tumours. By immunohistochemistry, cytosolic (abnormal) c-KIT expression was seen in four of the five cases. CAM5.2 immunoreactivity was detected in neoplastic cells of all ASGAC cases examined, whereas it was not evident in any case of perianal gland tumour. The findings suggest that c-KIT expression and its cellular localization may be important in the oncogenesis of ASGAC and CAM5.2 can be used to distinguish between ASGAC and perianal gland tumours.
ISSN:0021-9975
1532-3129
DOI:10.1016/j.jcpa.2022.07.010