The Effect of Endometrial Scratch on Pregnancy Rate in Women with Previous Intrauterine Insemination Failure: a Systematic Review and Meta-analysis of Randomized Controlled Trials

The objective of this study was to evaluate the impact of endometrial scratch on the pregnancy rate among women with previous failed intrauterine insemination (IUI). A systematic search was done in PubMed, Cochrane Library, Scopus, and ISI web of science from inception to November 2021. We selected...

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Published in:Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2023-05, Vol.30 (5), p.1399-1407
Main Authors: Baradwan, Saeed, Alshahrani, Majed Saeed, AlSghan, Rayan, Alkhamis, Waleed H., Alsharif, Saud Abdullah, Alanazi, Gharam Abdulrahman, Abdelwahed, Rania Mahfouz, Alkholy, Eman A., Fouad, Mahmoud, Saleh, Mohamed, Abdelati, Manal G., Alazazy, Hosam Eldin Mohamad, Elsenity, Mohamed A., Abdelhakim, Ahmed Mohamed, Mohamed, Mohamed Abdelsattar, Abbas, Ahmed M., Mojahed, Eman M.
Format: Article
Language:English
Subjects:
Embryology
Endometrium
Female
Fertilization in Vitro
Humans
Insemination
Insemination, Artificial
Live Birth
Medicine
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
Ovulation Induction
Pregnancy
Pregnancy Rate
Randomized Controlled Trials as Topic
Reproductive Medicine
Review
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Summary:The objective of this study was to evaluate the impact of endometrial scratch on the pregnancy rate among women with previous failed intrauterine insemination (IUI). A systematic search was done in PubMed, Cochrane Library, Scopus, and ISI web of science from inception to November 2021. We selected randomized clinical trials (RCTs) that compared endometrial scratch in the intervention group versus placebo or no intervention in the control group among infertile women with previous failure of IUI regarding different pregnancy outcomes. Revman software was utilized for performing our meta-analysis. Our main outcomes were biochemical pregnancy, clinical pregnancy, and live birth rates. Five RCTs met our inclusion criteria with a total number of 989 patients. We found endometrial scratch significantly improved the biochemical and clinical pregnancy rates in comparison with the control group among women with previous IUI failure ( p  
ISSN:1933-7191
1933-7205
DOI:10.1007/s43032-022-01081-z