Coadministration of L‐alanine and L‐glutamine ameliorate blood glucose levels, biochemical indices and histological features in alloxan‐induced diabetic rats

We evaluated the effects of supplementation of L‐alanine and L‐glutamine on blood glucose levels and biochemical parameters in alloxan‐induced diabetic rat. Forty‐nine animals were distributed into seven equal groups. Except for the non‐diabetic control, diabetes was induced in all groups by intrave...

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Published in:Journal of food biochemistry 2022-12, Vol.46 (12), p.e14420-n/a
Main Authors: Ezeonwumelu, Ifeanyi J., Mode, Abduljalil M., Magaji, Umar F., Nzoniwu, Nnamdi A., Tangaza, Muhamad H., Tanimu, Fatima I., Dandare, Shamsudeen U.
Format: Article
Language:English
Subjects:
Alanine - adverse effects
Alloxan - adverse effects
Animals
antioxidants
Antioxidants - therapeutic use
Blood Glucose - metabolism
diabetes mellitus
Diabetes Mellitus, Experimental - drug therapy
Diabetes Mellitus, Experimental - metabolism
Glutamine - adverse effects
hypoglycemic agents
Hypoglycemic Agents - pharmacology
L‐alanine
L‐glutamine
Rats
Rats, Wistar
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Summary:We evaluated the effects of supplementation of L‐alanine and L‐glutamine on blood glucose levels and biochemical parameters in alloxan‐induced diabetic rat. Forty‐nine animals were distributed into seven equal groups. Except for the non‐diabetic control, diabetes was induced in all groups by intravenous alloxan injection followed by daily supplementation with amino acids for 14 days. Weight and blood glucose were monitored during supplementation, while biochemical parameters such as liver and renal functions, lipid profile, and antioxidant markers were evaluated post‐intervention. A significant increase (p 
ISSN:0145-8884
1745-4514
DOI:10.1111/jfbc.14420