Comparison between the impact of tenofovir alafenamide and that of abacavir on rapid kidney function decline: A retrospective observational study

Objectives To compare the impact of tenofovir alafenamide (TAF) on the slope of the estimated glomerular filtration rate (eGFR) with that of abacavir in Japanese patients living with HIV infection. Methods The participants in this single‐centre, retrospective, observational study were Japanese patie...

Full description

Saved in:
Bibliographic Details
Published in:HIV medicine 2023-04, Vol.24 (4), p.422-430
Main Authors: Hikasa, Shinichi, Shimabukuro, Shota, Hideta, Kyoko, Higasa, Satoshi, Sawada, Akihiro, Tokugawa, Tazuko, Tanaka, Kuniyoshi, Yanai, Mina, Kimura, Takeshi
Format: Article
Language:English
Subjects:
Abacavir
Adenine - adverse effects
Anti-HIV Agents - adverse effects
Antiretroviral agents
Antiretroviral therapy
Data points
Dideoxynucleosides - adverse effects
Emtricitabine
Emtricitabine - therapeutic use
Epidermal growth factor receptors
Glomerular filtration rate
HIV
HIV infection
HIV Infections - drug therapy
Human immunodeficiency virus
Humans
Infections
Kidney
Kidneys
Lamivudine
Lamivudine - adverse effects
Observational studies
rapid kidney function decline
Regression analysis
Regression coefficients
Renal function
Retrospective Studies
Tenofovir
tenofovir alafenamide
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives To compare the impact of tenofovir alafenamide (TAF) on the slope of the estimated glomerular filtration rate (eGFR) with that of abacavir in Japanese patients living with HIV infection. Methods The participants in this single‐centre, retrospective, observational study were Japanese patients with HIV infection who started antiretroviral therapy with TAF/emtricitabine or abacavir/lamivudine or were switched from tenofovir disoproxil fumarate/emtricitabine to TAF/emtricitabine or abacavir/lamivudine (anchor drugs remained constant) between January 2012 and December 2020. The eGFR slope was defined as the regression coefficient between eGFR and time. The study outcome was rapid kidney function decline (RKFD; eGFR slope 
ISSN:1464-2662
1468-1293
DOI:10.1111/hiv.13408