Phenolic Glucosides from the Leaves of Vitex negundo var. cannabifolia

Four new phenolic glucosides, cannabifolins G–J (1–4), together with four known ones (5–8), were isolated from the leaves of Vitex negundo var. cannabifolia. Their structures were established by comprehensive analysis of 1D and 2D NMR data and comparison of their spectroscopic and physical data with...

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Bibliographic Details
Published in:Chemistry & biodiversity 2022-11, Vol.19 (11), p.e202200652-n/a
Main Authors: Sun, Jing, Li, Manman, Wang, Yongru, Chang, Chuang, Pei, Yujie, Zeng, Kewu, Zhao, Yunfang, Zheng, Jiao, Song, Yuelin, Tu, Pengfei, Huo, Huixia, Li, Jun
Format: Article
Language:English
Subjects:
anti-inflammation
Glucosides
Lipopolysaccharides
Microglial cells
Nitric oxide
NMR
Nuclear magnetic resonance
Phenolic compounds
phenolic glucosides
Phenols
Two dimensional analysis
Verbenaceae
Vitex negundo
Vitex negundo var. cannabifolia
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Summary:Four new phenolic glucosides, cannabifolins G–J (1–4), together with four known ones (5–8), were isolated from the leaves of Vitex negundo var. cannabifolia. Their structures were established by comprehensive analysis of 1D and 2D NMR data and comparison of their spectroscopic and physical data with the literature values. Compound 7 exhibited weak inhibition of nitric oxide production stimulated by lipopolysaccharide in BV‐2 microglial cells with IC50 value of 132.8 μM.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202200652