Flavonoids and their therapeutic applications in skin diseases

Flavonoids are a class of plant polyphenols found in a variety of fruits, vegetables, teas, and flowers. These compounds are present in many common dietary sources, such as green tea, wine, pomegranates, and turmeric, and possess a broad spectrum of biological activity due to their unique chemical s...

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Bibliographic Details
Published in:Archives of dermatological research 2023-04, Vol.315 (3), p.321-331
Main Authors: Ma, Emily Z., Khachemoune, Amor
Format: Article
Language:English
Subjects:
Alzheimer's disease
Antioxidants - pharmacology
Antioxidants - therapeutic use
Antiviral activity
Antiviral agents
Antiviral drugs
Biological activity
Dermatology
Disease prevention
Flavonoids
Flavonoids - pharmacology
Flavonoids - therapeutic use
Flowers
Green tea
Humans
Inflammation
Liver diseases
Medicine
Medicine & Public Health
Neurodegenerative diseases
Phenols
Polyphenols
Review
Skin cancer
Skin diseases
Skin Diseases - drug therapy
Skin Neoplasms - prevention & control
Tea
Therapeutic applications
Ultraviolet radiation
Ultraviolet Rays
Wound healing
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Summary:Flavonoids are a class of plant polyphenols found in a variety of fruits, vegetables, teas, and flowers. These compounds are present in many common dietary sources, such as green tea, wine, pomegranates, and turmeric, and possess a broad spectrum of biological activity due to their unique chemical structure. Flavonoids exhibit antioxidant, anti-inflammatory, antiviral, and anticarcinogenic properties that have been widely studied as potential therapeutics for diseases ranging from Alzheimer’s disease to liver disease. There is currently significant research into therapeutic benefits of flavonoids in various skin conditions as these compounds have been shown to absorb ultraviolet radiation and modulate cancer and inflammation signaling pathways. This review discusses the current research in the application of flavonoids in skin diseases (e.g., prevention of premature photoaging, prevention and treatment of skin cancer, and promotion of skin wound healing) and their proposed mechanisms to provide a basis for future basic and translational research of flavonoids as potential drugs in the prevention and treatment of skin disorders.
ISSN:1432-069X
0340-3696
1432-069X
DOI:10.1007/s00403-022-02395-3