Insights into established and emerging roles of SR protein family in plants and animals

Splicing of pre‐mRNA is an essential part of eukaryotic gene expression. Serine‐/arginine‐rich (SR) proteins are highly conserved RNA‐binding proteins present in all metazoans and plants. SR proteins are involved in constitutive and alternative splicing, thereby regulating the transcriptome and prot...

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Published in:Wiley interdisciplinary reviews. RNA 2023-05, Vol.14 (3), p.e1763-n/a
Main Authors: Kumar, Kundan, Sinha, Shubham Kumar, Maity, Upasana, Kirti, Pulugurtha Bharadwaja, Kumar, Koppolu Raja Rajesh
Format: Article
Language:English
Subjects:
abiotic stress
Alternative Splicing
Animals
biotic stress
cancer
development
Developmental stages
disease
Gene expression
Genomes
mRNA stability
mRNA turnover
Nuclear Proteins - genetics
Nuclear Proteins - metabolism
plant and metazoan
Proteins
Proteomes
RNA Precursors - genetics
RNA processing
RNA Splicing
RNA, Messenger - metabolism
Roles
Serine-Arginine Splicing Factors - genetics
Serine-Arginine Splicing Factors - metabolism
splicing factor
Transcriptomes
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Summary:Splicing of pre‐mRNA is an essential part of eukaryotic gene expression. Serine‐/arginine‐rich (SR) proteins are highly conserved RNA‐binding proteins present in all metazoans and plants. SR proteins are involved in constitutive and alternative splicing, thereby regulating the transcriptome and proteome diversity in the organism. In addition to their role in splicing, SR proteins are also involved in mRNA export, nonsense‐mediated mRNA decay, mRNA stability, and translation. Due to their pivotal roles in mRNA metabolism, SR proteins play essential roles in normal growth and development. Hence, any misregulation of this set of proteins causes developmental defects in both plants and animals. SR proteins from the animal kingdom are extensively studied for their canonical and noncanonical functions. Compared with the animal kingdom, plant genomes harbor more SR protein‐encoding genes and greater diversity of SR proteins, which are probably evolved for plant‐specific functions. Evidence from both plants and animals confirms the essential role of SR proteins as regulators of gene expression influencing cellular processes, developmental stages, and disease conditions. This article is categorized under: RNA Processing > Splicing Mechanisms RNA Processing > Splicing Regulation/Alternative Splicing Functional significance of SR protein family in plants and animals
ISSN:1757-7004
1757-7012
DOI:10.1002/wrna.1763