Co-Catalyzed Reductive Cyclization of Acrylate-Containing 1,6-Enynes

A Co-catalyzed reductive cyclization of acrylate-containing 1,6-enynes is reported, providing an approach to construct five-membered carbocyclic and heterocyclic scaffolds containing enol ethers and all-carbon quaternary carbons. This novel process enables an E/Z mixture of 1,6-enynes to react with...

Full description

Saved in:
Bibliographic Details
Published in:Journal of organic chemistry 2022-10, Vol.87 (19), p.13339-13345
Main Authors: Yang, Zhantao, Hou, Shenyin, Cheng, Yunfan, Sun, Li, Yang, Chun-Hua
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A Co-catalyzed reductive cyclization of acrylate-containing 1,6-enynes is reported, providing an approach to construct five-membered carbocyclic and heterocyclic scaffolds containing enol ethers and all-carbon quaternary carbons. This novel process enables an E/Z mixture of 1,6-enynes to react with good functional group tolerance and good isolated yields, in an operationally simple manner.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.2c01345