Treatments against Polymorphosal discrepancies in Glioblastoma Multiforme

Glioblastoma (GB) are aggressive tumors that obstruct normal brain function. While the skull cannot expand in response to cancer growth, the growing pressure in the brain is generally the first sign. It can produce more frequent headaches, unexplained nausea or vomiting, blurred peripheral vision, d...

Full description

Saved in:
Bibliographic Details
Published in:Metabolic brain disease 2023, Vol.38 (1), p.61-68
Main Authors: Mukerjee, Nobendu, Maitra, Swastika, Roy, Subhradeep, Modak, Shaswata, Hasan, Mohammad Mehedi, Chakraborty, Biswajit, Ghosh, Arabinda, Ghosh, Asmita, Kamal, Mohammad Amjad, Dey, Abhijit, Ashraf, Ghulam Md, Malik, Sumira, Rahman, Md. Habibur, Alghamdi, Badrah S., Abuzenadah, Adel Mohammad, Alexiou, Athanasios
Format: Article
Language:English
Subjects:
Arm
Biochemistry
Biomarkers
Biomedical and Life Sciences
Biomedicine
Brain
Brain - pathology
Brain cancer
Brain diseases
Brain Neoplasms - genetics
Brain Neoplasms - pathology
Brain research
Brain tumors
Breast cancer
Diabetes
Endothelial cells
Endothelial Cells - pathology
Erythrocytes
Genes
Genomes
Glioblastoma
Glioblastoma - genetics
Glioblastoma - pathology
Glioma
Humans
Localization
Medical prognosis
Medical research
Metabolic Diseases
Metabolism
Molecular biology
Neurology
Neurosciences
Nucleotides
Oncology
Peripheral vision
Protein synthesis
Proteins
Research centers
Review Article
Rheumatoid arthritis
Science
Single-nucleotide polymorphism
Tumors
Vomiting
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Glioblastoma (GB) are aggressive tumors that obstruct normal brain function. While the skull cannot expand in response to cancer growth, the growing pressure in the brain is generally the first sign. It can produce more frequent headaches, unexplained nausea or vomiting, blurred peripheral vision, double vision, a loss of feeling or movement in an arm or leg, and difficulty speaking and concentrating; all depend on the tumor’s location. GB can also cause vascular thrombi, damaging endothelial cells and leading to red blood cell leakage. Latest studies have revealed the role of single nucleotide polymorphisms (SNPs) in developing and spreading cancers such as GB and breast cancer. Many discovered SNPs are associated with GB, particularly in great abundance in the promoter region, creating polygenetic vulnerability to glioma. This study aims to compile a list of some of the most frequent and significant SNPs implicated with GB formation and proliferation.
ISSN:0885-7490
1573-7365
DOI:10.1007/s11011-022-01082-6